tert-butyl 4-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-1-piperazinecarboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-1-piperazinecarboxylate
CAS No.:1361218-41-8
Molecular Formula:C₁₈H₂₅F₃N₂O₃
Molecular Weight:374.403
Hs Code.:

Synonyms:tert-butyl 4-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-1-piperazinecarboxylate

Suppliers and Price of tert-butyl 4-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-1-piperazinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 4-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-1-piperazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-1-piperazinecarboxylate

There total 2 articles about tert-butyl 4-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122243-28-1
2‐(4‐bromophenyl)‐1,1,1‐trifluoropropan‐2‐ol

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1361218-41-8
tert-butyl 4-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-1-piperazinecarboxylate

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; In toluene; at 100 ℃; for 2h; Product distribution / selectivity; sealed tube;

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 1361218-41-8
tert-butyl 4-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexanes / 0.25 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / toluene / 2 h / 100 °C / sealed tube

With n-butyllithium; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; In hexanes; diethyl ether; toluene;