(2RS,5S)-2-benzyl-5-<(benzyloxycarbonyl)amino>-7-methyl-4-oxooctanoic acid

Base Information

Chemical Name:(2RS,5S)-2-benzyl-5-<(benzyloxycarbonyl)amino>-7-methyl-4-oxooctanoic acid
CAS No.:118404-36-7
Molecular Formula:C₂₄H₂₉NO₅
Molecular Weight:411.498
Hs Code.:

Synonyms:(2RS,5S)-2-benzyl-5-<(benzyloxycarbonyl)amino>-7-methyl-4-oxooctanoic acid

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Chemical Property of (2RS,5S)-2-benzyl-5-<(benzyloxycarbonyl)amino>-7-methyl-4-oxooctanoic acid

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Technology Process of (2RS,5S)-2-benzyl-5-<(benzyloxycarbonyl)amino>-7-methyl-4-oxooctanoic acid

There total 5 articles about (2RS,5S)-2-benzyl-5-<(benzyloxycarbonyl)amino>-7-methyl-4-oxooctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2018-66-8
Z-Leu-OH

: 118404-36-7
(2RS,5S)-2-benzyl-5-<(benzyloxycarbonyl)amino>-7-methyl-4-oxooctanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1) isobutyl chloroformate, TEA / 1) Et₂O, -15 deg C, 15 min, 2) Et₂O, -15 deg C, 2 h

2: 96 percent / HBr / diethyl ether / 5 °C

3: 1) NaH, HMPA, 2) HMPA / 1) DMF, 25 deg C, 40 min, 2) DMF, 25 deg C, 2 h

4: 1 N NaOH / ethanol

5: pyridine / 0.5 h / 100 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; TEA; hydrogen bromide; sodium hydride; isobutyl chloroformate; In pyridine; diethyl ether; ethanol;
DOI:10.1021/jm00126a039

Reference yield:

: 102123-81-9
(3-diazo-1-(S)-(2-methylpropyl)-2-oxopropyl)carbamic acid benzyl ester

: 118404-36-7
(2RS,5S)-2-benzyl-5-<(benzyloxycarbonyl)amino>-7-methyl-4-oxooctanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / HBr / diethyl ether / 5 °C

2: 1) NaH, HMPA, 2) HMPA / 1) DMF, 25 deg C, 40 min, 2) DMF, 25 deg C, 2 h

3: 1 N NaOH / ethanol

4: pyridine / 0.5 h / 100 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; hydrogen bromide; sodium hydride; In pyridine; diethyl ether; ethanol;
DOI:10.1021/jm00126a039

Reference yield:

: 118252-77-0
(3S)-3-<(benzyloxycarbonyl)amino>-1-bromo-5-methyl-2-oxohexane

: 118404-36-7
(2RS,5S)-2-benzyl-5-<(benzyloxycarbonyl)amino>-7-methyl-4-oxooctanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaH, HMPA, 2) HMPA / 1) DMF, 25 deg C, 40 min, 2) DMF, 25 deg C, 2 h

2: 1 N NaOH / ethanol

3: pyridine / 0.5 h / 100 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; sodium hydride; In pyridine; ethanol;
DOI:10.1021/jm00126a039