ethyl 3-bromo-3-(4-benzyloxy-2-bromophenyl)-2-oxopropanoate

Base Information

• Chemical Name: ethyl 3-bromo-3-(4-benzyloxy-2-bromophenyl)-2-oxopropanoate
• CAS No.: 1338067-80-3
• Molecular Formula: C₁₈H₁₆Br₂O₄
• Molecular Weight: 456.131
• Mol file: 1338067-80-3.mol

Synonyms:ethyl 3-bromo-3-(4-benzyloxy-2-bromophenyl)-2-oxopropanoate

Chemical Property of ethyl 3-bromo-3-(4-benzyloxy-2-bromophenyl)-2-oxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-bromo-3-(4-benzyloxy-2-bromophenyl)-2-oxopropanoate

There total 6 articles about ethyl 3-bromo-3-(4-benzyloxy-2-bromophenyl)-2-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-4-hydroxybenzaldehyde (22532-60-1) → ethyl 3-bromo-3-(4-benzyloxy-2-bromophenyl)-2-oxopropanoate (1338067-80-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 70 °C

2: tetrahydrofuran; ethanol / 6 h / 0 °C / Reflux

3: magnesium bromide / diethyl ether / 2 h / 20 °C

With potassium carbonate; magnesium bromide; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; 2: Darzens condensation;

DOI:10.1021/ol201332u

Reference yield:

ethyl 3-(4-benzyloxy-2-bromophenyl)-2-ethoxyoxirane-2-carboxylate (1312466-17-3) → ethyl 3-bromo-3-(4-benzyloxy-2-bromophenyl)-2-oxopropanoate (1338067-80-3)

Guidance literature:

With magnesium bromide; In diethyl ether; at 20 ℃; for 2h;

DOI:10.1021/ol201332u

Reference yield:

benzyl bromide (100-39-0) → ethyl 3-bromo-3-(4-benzyloxy-2-bromophenyl)-2-oxopropanoate (1338067-80-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 70 °C

2: tetrahydrofuran; ethanol / 6 h / 0 °C / Reflux

3: magnesium bromide / diethyl ether / 2 h / 20 °C

With potassium carbonate; magnesium bromide; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; 2: Darzens condensation;

DOI:10.1021/ol201332u

upstream raw materials:

ethyl 3-(4-benzyloxy-2-bromophenyl)-2-ethoxyoxirane-2-carboxylate

2-bromo-4-hydroxybenzaldehyde

benzyl bromide

4-hydroxy-benzaldehyde

Downstream raw materials:

C₂₇H₂₇BrO₈

ethyl 6-(3-hydroxypropoxy)-2-(4-(benzyloxy)-2-bromophenyl)-2,3-dihydro-3,4-dihydroxybenzofuran-3-carboxylate

3-(ethoxycarbonyl)-6-(3-hydroxypropoxy)-2-(4-(benzyloxy)-2-bromophenyl)-2,3-dihydro-3-hydroxybenzofuran-4-yl 4-methylbenzenesulfonate

6-(3-hydroxypropoxy)-2-(4-(benzyloxy)-2-bromophenyl)-2,3-dihydro-3-hydroxy-3-(hydroxymethyl)benzofuran-4-yl 4-methylbenzenesulfonate