22532-60-1

Basic information

• Product Name: Benzaldehyde, 2-broMo-4-hydroxy
• Synonyms: Benzaldehyde, 2-broMo-4-hydroxy;2-BroMo-4-Hydroxy benzaldehyde
• CAS NO: 22532-60-1
• Molecular Formula: C₇H₅BrO₂
• Molecular Weight: 201.0174
• EINECS: -0
• Mol File: 22532-60-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 292.4±20.0 °C(Predicted)
• Appearance: /
• Density: 1.737±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.81±0.18(Predicted)
• CAS DataBase Reference: Benzaldehyde, 2-broMo-4-hydroxy(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 2-broMo-4-hydroxy(22532-60-1)
• EPA Substance Registry System: Benzaldehyde, 2-broMo-4-hydroxy(22532-60-1)

Safety Data

• Hazardous Substances Data: 22532-60-1(Hazardous Substances Data)

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 106-44-5 p-cresol 
• 108-95-2 phenol 
• 43192-31-0 2-bromo-4-methoxybenzaldehyde 
• 82380-17-4 2-bromo-4-hydroxybenzonitrile 
• 36282-26-5 2-bromo-4-fluorobenzonitrile 
• 83521-93-1 4-(1,3-dimethylimidazolidin-2-yl)phenol 
• 64-17-5 ethanol 
• 591-20-8 3-Bromophenol 
• 67-66-3 chloroform 
• 75-25-2 Bromoform 
• 74-90-8 hydrogen cyanide 

Downstream Products

• 1281885-10-6 2-bromo-4-(3-bromopropoxy)benzaldehyde 
• 1281885-12-8 4-(3-bromopropoxy)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 
• 69393-95-9 6a,11a-dihydro-6H-benzofuro[3,2-c]chromen-3,6a,9-triol 
• 1312466-17-3 ethyl 3-(4-benzyloxy-2-bromophenyl)-2-ethoxyoxirane-2-carboxylate 
• 1338067-80-3 ethyl 3-bromo-3-(4-benzyloxy-2-bromophenyl)-2-oxopropanoate 
• 1312466-18-4 C₂₇H₂₇BrO₈ 
• 1312466-19-5 ethyl 6-(3-hydroxypropoxy)-2-(4-(benzyloxy)-2-bromophenyl)-2,3-dihydro-3,4-dihydroxybenzofuran-3-carboxylate 
• 1312466-20-8 3-(ethoxycarbonyl)-6-(3-hydroxypropoxy)-2-(4-(benzyloxy)-2-bromophenyl)-2,3-dihydro-3-hydroxybenzofuran-4-yl 4-methylbenzenesulfonate 
• 1312466-21-9 6-(3-hydroxypropoxy)-2-(4-(benzyloxy)-2-bromophenyl)-2,3-dihydro-3-hydroxy-3-(hydroxymethyl)benzofuran-4-yl 4-methylbenzenesulfonate 
• 1312466-22-0 9-(3-hydroxypropoxy)-3-(benzyloxy)-6a,11a-dihydro-6a-hydroxy-6H-benzofuro[3,2-c]chromen-7-yl 4-methylbenzenesulfonate 
• 1312466-23-1 9-(3-hydroxypropoxy)-3-(benzyloxy)-6a,11a-dihydro-6H-benzofuro[3,2-c]chromen-6a-ol 
• 1312466-24-2 3-benzyloxy-6a,11a-dihydro-6H-benzofuro[3,2-c]chromen-6a,9-diol 
• 227603-76-1 4-(benzyloxy)-2-bromobenzaldehyde 
• 1415599-23-3 tert-butyl N-[(1R)-1-[[6-[(3,3-dimethyl-1H-isobenzofuran-5-yl)oxy]-3-pyridyl]carbamoyl]propyl]carbamate 

Relevant articles and documents

Selective Bromination of β-Positions of Porphyrin by Self-Catalytic Behaviour of VOTPP: Facile Synthesis, Electrochemical Redox Properties and Catalytic Application

Oxidovanadium(IV) complex of β-octabromo-meso-tetraphenylporphyrin, {[VIVO(TPPBr8)], 2} was synthesized by self-catalytic oxidative bromination of meso-tetraphenylporphyrinatooxidovanadium(IV) {[VIVO(TPP), 1} in excellent yield under mild conditions at 25 °C and its structure was confirmed by single crystal X-ray study. UV-Vis and 1H NMR spectra further confirmed that the meso-phenyl rings are not brominated and thus emphasizes on the selectivity as well as synthetic importance of this catalytic method. In the presence of substrates e. g. phenol derivatives, 1 biomimics the vanadium bromoperoxidase (VBPO) enzyme and catalyses the oxidative bromination of substrates in water at 25 °C. Remarkably, 2 also catalyses the oxidative bromination of phenol derivatives under similar reaction conditions with very high turnover frequency (TOF) values (ca. 29 s?1) along with its recyclability. It was found that 2 showed superior catalytic performance as compared to 1 because of its electron deficient nature due to electron withdrawing bromo substituents and robust saddle shaped nonplanar structure (further supported by DFT studies).

Synthesis method of 2-methoxy-4-hydroxypropiophenone

The present invention discloses a synthesis method of 2-methoxy-4-hydroxypropiophenone, and belongs to the field of organic synthesis chemistry. According to the synthesis method disclosed by the present invention, the method comprises the following steps: using phenol as a raw martial; firstly adding a CH3I solution and sodium hydroxide into the phenol to generate p-methylphenol; then adding two oxides such as CaO2 and magnesium oxide into the p-methylphenol to generate p-hydroxybenzaldehyde; then adding a bromine solution and HAC into the p-hydroxybenzaldehyde to further generate 2-bromo-p-hydroxybenzaldehyde; then synthesizing 2-nitro-1-(2-bromo-4-hydroxy)propenyl benzene by adding nitroethan dropwise; adding a solution of Fe and HCl into the 2-nitro-1-(2-bromo-4-hydroxy)propenyl benzene to generate 2-bromo-4-hydroxypropiophenone; and finally adding methanol and PCl3 to finally generate the 2-methoxy-4-hydroxypropiophenone disclosed by the present invention. The embodiment demonstrates that the method disclosed by the present invention is not only simple in operation and low in production cost, but also has a relatively mild reaction process, and the recovery rate is significantly improved and reaches up to more than 85%.

HYDANTOIN DERIVATES AS KV3 INHIBITORS

The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.