(1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-(2-naphthalen-2-yl-ethyl) ester 3-phenyl ester

Base Information

Chemical Name:(1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-(2-naphthalen-2-yl-ethyl) ester 3-phenyl ester
CAS No.:134958-86-4
Molecular Formula:C₃₁H₃₃NO₅
Molecular Weight:499.607
Hs Code.:

Synonyms:(1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-(2-naphthalen-2-yl-ethyl) ester 3-phenyl ester

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Chemical Property of (1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-(2-naphthalen-2-yl-ethyl) ester 3-phenyl ester

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Technology Process of (1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-(2-naphthalen-2-yl-ethyl) ester 3-phenyl ester

There total 4 articles about (1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-(2-naphthalen-2-yl-ethyl) ester 3-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 126295-11-2,135030-02-3
(1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 2-naphthalen-2-yl-ethyl ester

: 1885-14-9
phenyl chloroformate

: 134958-86-4
(1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-(2-naphthalen-2-yl-ethyl) ester 3-phenyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; Heating;
DOI:10.1016/S0040-4020(01)81785-3

Reference yield:

: 1485-07-0
naphthalen-2-ethanol

: 134958-86-4
(1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-(2-naphthalen-2-yl-ethyl) ester 3-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / DMAP / CH₂Cl₂ / Heating

2: 1) LIBH₄, 2) TFA, Et₃SiH / 1) THF, 0 deg C, 2) CH₂Cl₂

3: 89 percent / i-Pr₂NEt / CH₂Cl₂ / Heating

With triethylsilane; dmap; lithium borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0040-4020(01)81785-3

Reference yield:

: 109216-50-4
(1S,5R,7S)-1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carbonyl chloride

: 134958-86-4
(1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-(2-naphthalen-2-yl-ethyl) ester 3-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / DMAP / CH₂Cl₂ / Heating

2: 1) LIBH₄, 2) TFA, Et₃SiH / 1) THF, 0 deg C, 2) CH₂Cl₂

3: 89 percent / i-Pr₂NEt / CH₂Cl₂ / Heating

With triethylsilane; dmap; lithium borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0040-4020(01)81785-3