N-(4-{4-(2-(dimethylamino)ethoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Base Information

Chemical Name:N-(4-{4-(2-(dimethylamino)ethoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide
CAS No.:1439936-49-8
Molecular Formula:C₂₁H₂₄N₄O₂S
Molecular Weight:396.513
Hs Code.:

Synonyms:N-(4-{4-(2-(dimethylamino)ethoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

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Chemical Property of N-(4-{4-(2-(dimethylamino)ethoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Chemical Property:

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Technology Process of N-(4-{4-(2-(dimethylamino)ethoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

There total 4 articles about N-(4-{4-(2-(dimethylamino)ethoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439935-97-3
N-(4-(4-hydroxy-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide

: 107-99-3
2-(dimethylamino)ethyl chloride

: 1439936-49-8
N-(4-{4-(2-(dimethylamino)ethoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;

Reference yield:

: 1439935-96-2
4-(2-aminothiazol-4-yl)-3,5-dimethylphenol

: 1439936-49-8
N-(4-{4-(2-(dimethylamino)ethoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 91060-92-3
1-(4-hydroxy-2,6-dimethylphenyl)ethanone

: 1439936-49-8
N-(4-{4-(2-(dimethylamino)ethoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutylammomium bromide / acetonitrile / 1.5 h / 20 °C

2: ethanol / 2 h / Reflux

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

4: sodium hydride / N,N-dimethyl-formamide

With tetrabutylammomium bromide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; N,N-dimethyl-formamide; acetonitrile;