tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-phenyl)(ethyl)amino)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-phenyl)(ethyl)amino)piperidine-1-carboxylate
• CAS No.: 1403258-24-1
• Molecular Formula: C₂₈H₃₉BrN₄O₄
• Molecular Weight: 575.546
• Mol file: 1403258-24-1.mol

Synonyms:tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-phenyl)(ethyl)amino)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-phenyl)(ethyl)amino)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-phenyl)(ethyl)amino)piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-phenyl)(ethyl)amino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.96%

3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one (771579-27-2) + C20H29BrN2O4 (1403258-25-2) → tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-phenyl)(ethyl)amino)piperidine-1-carboxylate (1403258-24-1)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃;

Reference yield:

5-bromo-2-methyl-3-nitrobenzoic acid methyl ester (220514-28-3) → tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-phenyl)(ethyl)amino)piperidine-1-carboxylate (1403258-24-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

2.1: acetic acid / 1,1-dichloroethane / 0.17 h / 20 °C

2.2: 0 - 20 °C

3.1: acetic acid / 1,1-dichloroethane / 0.17 h / 20 °C

3.2: 2 h / 0 - 20 °C

4.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

4.2: pH 6

4.3: pH 4

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; iron; ammonium chloride; acetic acid; sodium hydroxide; In 1,1-dichloroethane; ethanol; water; dimethyl sulfoxide;

Reference yield:

2-methyl-3-amino-5-bromobenzoic acid methyl ester (1000342-11-9) → tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-phenyl)(ethyl)amino)piperidine-1-carboxylate (1403258-24-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetic acid / 1,1-dichloroethane / 0.17 h / 20 °C

1.2: 0 - 20 °C

2.1: acetic acid / 1,1-dichloroethane / 0.17 h / 20 °C

2.2: 2 h / 0 - 20 °C

3.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

3.2: pH 6

3.3: pH 4

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; acetic acid; sodium hydroxide; In 1,1-dichloroethane; ethanol; dimethyl sulfoxide;

upstream raw materials:

5-bromo-2-methyl-3-nitrobenzoic acid methyl ester

2-methyl-3-nitrobenzic acid

5-bromo-2-methylbenzoic acid

2-methyl-3-amino-5-bromobenzoic acid methyl ester

Downstream raw materials:

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(1-(methylsulfonyl)piperidin-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

5-(ethylpiperidin-4-ylamino)-4-methyl-4′-morpholin-4-ylmethylbiphenyl-3-carboxylic acid (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-ylmethyl)amide

5-((1-acetylpiperidin-4-yl)(ethyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

tert-butyl 4-((5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-yl)(ethyl)amino)piperidine-1-carboxylate