chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthol

Base Information

Chemical Name:chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthol
CAS No.:337521-03-6
Molecular Formula:C₃₆H₃₁ClN₂O₂
Molecular Weight:559.107
Hs Code.:

Synonyms:chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthol

Suppliers and Price of chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthol

There total 4 articles about chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 337520-99-7
1-(6-{[tert-butyl(dimethyl)silyl]oxy}-5-chloro-2-naphthyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propan-1-ol

: 337521-03-6
chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 15231-91-1
6-bromo-naphthalen-2-ol

: 337521-03-6
chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuryl dichloride / diethyl ether / 1 h / 0 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 0 °C

3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -70 °C

3.2: 0.83 h / -70 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

With 1H-imidazole; n-butyllithium; sulfuryl dichloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 337521-01-4
6-bromo-2-[(tert-butyldimethylsilyl)oxy]-1-chloronaphthalene

: 337521-03-6
chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthol

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -70 °C

1.2: 0.83 h / -70 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/j.bmc.2011.01.017