1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthyl trifluoromethanesulfonate

Base Information

Chemical Name:1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthyl trifluoromethanesulfonate
CAS No.:337521-05-8
Molecular Formula:C₃₇H₃₀ClF₃N₂O₄S
Molecular Weight:691.17
Hs Code.:

Synonyms:1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthyl trifluoromethanesulfonate

Suppliers and Price of 1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthyl trifluoromethanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthyl trifluoromethanesulfonate

There total 6 articles about 1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 337521-03-6
chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthol

: 358-23-6
trifluoromethylsulfonic anhydride

: 337521-05-8
1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthyl trifluoromethanesulfonate

Guidance literature:: With pyridine; at 0 ℃; for 1h;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 337521-03-6
chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthol

: 337521-05-8
1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthyl trifluoromethanesulfonate

Guidance literature:

Reference yield:

: 15231-91-1
6-bromo-naphthalen-2-ol

: 337521-05-8
1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuryl dichloride / diethyl ether / 1 h / 0 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 0 °C

3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -70 °C

3.2: 0.83 h / -70 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

5.1: pyridine / 1 h / 0 °C

With pyridine; 1H-imidazole; n-butyllithium; sulfuryl dichloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.017