methyl-1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate

Base Information

Chemical Name:methyl-1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate
CAS No.:337521-07-0
Molecular Formula:C₃₈H₃₃ClN₂O₃
Molecular Weight:601.145
Hs Code.:

Synonyms:methyl-1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate

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Chemical Property of methyl-1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate

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Technology Process of methyl-1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate

There total 7 articles about methyl-1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 67-56-1
methanol

: 337521-05-8
1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthyl trifluoromethanesulfonate

: 201230-82-2
carbon monoxide

: 337521-07-0
methyl-1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 14h; under 760.051 Torr;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 15231-91-1
6-bromo-naphthalen-2-ol

: 337521-07-0
methyl-1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuryl dichloride / diethyl ether / 1 h / 0 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 0 °C

3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -70 °C

3.2: 0.83 h / -70 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

5.1: pyridine / 1 h / 0 °C

6.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 14 h / 70 °C / 760.05 Torr

With pyridine; 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; n-butyllithium; sulfuryl dichloride; tetrabutyl ammonium fluoride; palladium diacetate; triethylamine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 337521-01-4
6-bromo-2-[(tert-butyldimethylsilyl)oxy]-1-chloronaphthalene

: 337521-07-0
methyl-1-chloro-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -70 °C

1.2: 0.83 h / -70 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

3.1: pyridine / 1 h / 0 °C

4.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 14 h / 70 °C / 760.05 Torr

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; n-butyllithium; tetrabutyl ammonium fluoride; palladium diacetate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.017