3-(1-(2-fluorobenzyl)-3-(5-fluoropyridin-2-yl)-1H-pyrazol-5-yl)isoxazole

Base Information

Chemical Name:3-(1-(2-fluorobenzyl)-3-(5-fluoropyridin-2-yl)-1H-pyrazol-5-yl)isoxazole
CAS No.:1446359-15-4
Molecular Formula:C₁₈H₁₂F₂N₄O
Molecular Weight:338.316
Hs Code.:

Synonyms:3-(1-(2-fluorobenzyl)-3-(5-fluoropyridin-2-yl)-1H-pyrazol-5-yl)isoxazole

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Chemical Property of 3-(1-(2-fluorobenzyl)-3-(5-fluoropyridin-2-yl)-1H-pyrazol-5-yl)isoxazole

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Technology Process of 3-(1-(2-fluorobenzyl)-3-(5-fluoropyridin-2-yl)-1H-pyrazol-5-yl)isoxazole

There total 1 articles about 3-(1-(2-fluorobenzyl)-3-(5-fluoropyridin-2-yl)-1H-pyrazol-5-yl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 915720-54-6
1-(5-fluoropyridin-2-yl)ethan-1-one

: 1216246-45-5
(2-fluorobenzyl)hydrazine hydrochloride salt

: 53064-54-3
isoxazole-3-carbonyl chloride

: 1446359-15-4
3-(1-(2-fluorobenzyl)-3-(5-fluoropyridin-2-yl)-1H-pyrazol-5-yl)isoxazole

Guidance literature:: 1-(5-fluoropyridin-2-yl)ethan-1-one; With lithium hexamethyldisilazane; In toluene; at 0 ℃; for 0.0833333h;

isoxazole-3-carbonyl chloride; In toluene; at 25 ℃; for 0.0833333h;

(2-fluorobenzyl)hydrazine hydrochloride salt; With hydrogenchloride; In ethanol; toluene; at 100 ℃; for 2h;

Reference yield:

: 1446359-15-4
3-(1-(2-fluorobenzyl)-3-(5-fluoropyridin-2-yl)-1H-pyrazol-5-yl)isoxazole

: 108-24-7
acetic anhydride

: 1446359-95-0
3-fluoro-6-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyridin-2-yl acetate

Guidance literature:: 3-(1-(2-fluorobenzyl)-3-(5-fluoropyridin-2-yl)-1H-pyrazol-5-yl)isoxazole; With dihydrogen peroxide; urea; trifluoroacetic anhydride; In dichloromethane; at 0 - 25 ℃;

acetic anhydride; at 145 ℃; for 4h;

Reference yield:

: 1446359-15-4
3-(1-(2-fluorobenzyl)-3-(5-fluoropyridin-2-yl)-1H-pyrazol-5-yl)isoxazole

: 1446359-16-5
C₁₈H₁₂F₂N₄O₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic anhydride; urea; dihydrogen peroxide / dichloromethane / 0 - 25 °C

1.2: 4 h / 145 °C

2.1: potassium carbonate; methanol / 0.5 h / 65 °C

With methanol; dihydrogen peroxide; potassium carbonate; urea; trifluoroacetic anhydride; In dichloromethane;