2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-5-fluoro-N-methoxybenzamide

Base Information

Chemical Name:2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-5-fluoro-N-methoxybenzamide
CAS No.:1201935-97-8
Molecular Formula:C₁₄H₁₀ClF₄N₃O₂
Molecular Weight:363.699
Hs Code.:

Synonyms:2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-5-fluoro-N-methoxybenzamide

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Chemical Property of 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-5-fluoro-N-methoxybenzamide

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Technology Process of 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-5-fluoro-N-methoxybenzamide

There total 3 articles about 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-5-fluoro-N-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1201935-98-9
2-amino-5-fluoro-N-methoxybenzamide

: 505084-55-9
2-chloro-4-iodo-5-(trifluoromethyl)pyridine

: 1201935-97-8
2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-5-fluoro-N-methoxybenzamide

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 90 ℃; for 5h; regioselective reaction; Inert atmosphere;
DOI:10.1080/00397911.2010.520403

Reference yield:

: 321-69-7
5-fluoroisatoic anhydride

: 1201935-97-8
2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-5-fluoro-N-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 5 °C

1.2: 5 - 20 °C

2.1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 5 h / 90 °C / Inert atmosphere

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In 1,4-dioxane; water; 2.1: Buchwald-Hartwig reaction;
DOI:10.1080/00397911.2010.520403

Reference yield:

: 446-08-2
2-amino-5-fluorobenzoic acid

: 1201935-97-8
2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-5-fluoro-N-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; toluene / 10 - 20 °C

2.1: sodium hydroxide / water / 5 °C

2.2: 5 - 20 °C

3.1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 5 h / 90 °C / Inert atmosphere

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In 1,4-dioxane; water; toluene; 3.1: Buchwald-Hartwig reaction;
DOI:10.1080/00397911.2010.520403