4-methoxybenzyl-[4-[2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl]amine

Base Information

Chemical Name:4-methoxybenzyl-[4-[2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl]amine
CAS No.:200801-20-3
Molecular Formula:C₂₇H₂₇F₃N₆O
Molecular Weight:508.546
Hs Code.:

Synonyms:4-methoxybenzyl-[4-[2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl]amine

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Chemical Property of 4-methoxybenzyl-[4-[2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl]amine

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Technology Process of 4-methoxybenzyl-[4-[2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl]amine

There total 10 articles about 4-methoxybenzyl-[4-[2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 200801-93-0
4-[5-(2-(4-methoxybenzylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester

: 200801-20-3
4-methoxybenzyl-[4-[2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl]amine

Guidance literature:: With hydrogen bromide; acetic acid; In dichloromethane; for 0.5h;
DOI:10.1021/jm9805236

Reference yield:

: 1336-21-6
ammonium hydroxide

: 200801-93-0
4-[5-(2-(4-methoxybenzylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester

: 200801-20-3
4-methoxybenzyl-[4-[2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl]amine

Guidance literature:: With hydrogen bromide; In methanol; dichloromethane; sodium hydrogencarbonate; acetic acid;

Reference yield:

: 14001-63-9
2-methylthio-4-methylpyrimidine

: 200801-20-3
4-methoxybenzyl-[4-[2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl]amine

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 5 min

2: 100 percent / aq. NaNO₂, HOAc / 1 h / 5 - 20 °C

3: 97 percent / ammonium acetate, AcOH / 2 h / Heating

4: TiCl₃, aq. HCl / methanol / 3 h / 20 °C

5: 100 percent / Oxone / methanol / 4 h / 20 °C

6: 92 percent / 0.17 h / 140 °C

7: 23 percent / HBr, AcOH / CH₂Cl₂ / 0.5 h

With ammonium acetate; hydrogenchloride; Oxone; titanium(III) chloride; hydrogen bromide; acetic acid; lithium diisopropyl amide; sodium nitrite; In methanol; dichloromethane;
DOI:10.1021/jm9805236