4-[5-(2-(4-methoxybenzylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester

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Chemical Name:4-[5-(2-(4-methoxybenzylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester
CAS No.:200801-93-0
Molecular Formula:C₃₅H₃₃F₃N₆O₃
Molecular Weight:642.681
Hs Code.:

Synonyms:4-[5-(2-(4-methoxybenzylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester

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Chemical Property of 4-[5-(2-(4-methoxybenzylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester

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Technology Process of 4-[5-(2-(4-methoxybenzylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester

There total 8 articles about 4-[5-(2-(4-methoxybenzylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2393-23-9
4-methoxy-benzylamine

: 200801-92-9
5-<2-(methylsulfonyl)pyrimidin-4-yl>-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole

: 200801-93-0
4-[5-(2-(4-methoxybenzylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: at 140 ℃; for 0.166667h;
DOI:10.1021/jm9805236

Reference yield:

: 14001-63-9
2-methylthio-4-methylpyrimidine

: 200801-93-0
4-[5-(2-(4-methoxybenzylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 5 min

2: 100 percent / aq. NaNO₂, HOAc / 1 h / 5 - 20 °C

3: 97 percent / ammonium acetate, AcOH / 2 h / Heating

4: TiCl₃, aq. HCl / methanol / 3 h / 20 °C

5: 100 percent / Oxone / methanol / 4 h / 20 °C

6: 92 percent / 0.17 h / 140 °C

With ammonium acetate; hydrogenchloride; Oxone; titanium(III) chloride; acetic acid; lithium diisopropyl amide; sodium nitrite; In methanol;
DOI:10.1021/jm9805236

Reference yield:

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 200801-93-0
4-[5-(2-(4-methoxybenzylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / Et₃N / CH₂Cl₂ / 0.5 h / 5 °C

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 5 min

3: 100 percent / aq. NaNO₂, HOAc / 1 h / 5 - 20 °C

4: 97 percent / ammonium acetate, AcOH / 2 h / Heating

5: TiCl₃, aq. HCl / methanol / 3 h / 20 °C

6: 100 percent / Oxone / methanol / 4 h / 20 °C

7: 92 percent / 0.17 h / 140 °C

With ammonium acetate; hydrogenchloride; Oxone; titanium(III) chloride; acetic acid; triethylamine; lithium diisopropyl amide; sodium nitrite; In methanol; dichloromethane;
DOI:10.1021/jm9805236