6-amino-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Base Information

Chemical Name:6-amino-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide
CAS No.:1193345-99-1
Molecular Formula:C₁₉H₁₇FN₂O₂
Molecular Weight:324.355
Hs Code.:

Synonyms:6-amino-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

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Chemical Property of 6-amino-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

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Technology Process of 6-amino-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

There total 8 articles about 6-amino-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-nitrobenzofuran-3-carboxamide

: 1193345-99-1
6-amino-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: 5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-nitrobenzofuran-3-carboxamide; With 5%-palladium/activated carbon; hydrogen; In tetrahydrofuran; ethanol; under 2068.65 Torr;

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; under 2068.65 Torr;
DOI:10.1021/acs.jmedchem.8b01719

Reference yield:

ethyl 5-cyclopropyl-2-(4-fluorophenyl)-6-nitrobenzofuran-3-carboxylate: 691857-52-0
ethyl 5-cyclopropyl-2-(4-fluorophenyl)-6-nitrobenzofuran-3-carboxylate

: 1193345-99-1
6-amino-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide; water / ethanol / 0.33 h / 80 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.55 h / 20 °C / Inert atmosphere

3: hydrogen; 5% platinum on aluminium oxide / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With 5% platinum on aluminium oxide; water; hydrogen; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.joc.5b01598

Reference yield:

: C₁₇H₁₂Br₂FNO₅

: 1193345-99-1
6-amino-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide / N,N-dimethyl-formamide / 20 h / 60 °C / Inert atmosphere

2: potassium carbonate; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether / toluene; water / 2 h / 70 °C / Inert atmosphere

3: potassium hydroxide; water / ethanol / 0.33 h / 80 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.55 h / 20 °C / Inert atmosphere

5: hydrogen; 5% platinum on aluminium oxide / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With copper(l) iodide; 5% platinum on aluminium oxide; water; hydrogen; palladium diacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; bis[2-(diphenylphosphino)phenyl] ether; potassium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; 2: |Suzuki Coupling;
DOI:10.1021/acs.joc.5b01598