691857-52-0Relevant articles and documents
Conversion of a Benzofuran Ester to an Amide through an Enamine Lactone Pathway: Synthesis of HCV Polymerase Inhibitor GSK852A
Bowman, Roy K.,Bullock, Kae M.,Copley, Royston C. B.,Deschamps, Nicole M.,McClure, Michael S.,Powers, Jeremiah D.,Wolters, Andy M.,Wu, Lianming,Xie, Shiping
, p. 9610 - 9619 (2015)
HCV NS5B polymerase inhibitor GSK852A (1) was synthesized in only five steps from ethyl 4-fluorobenzoylacetate (3) in 46% overall yield. Key to the efficient route was the synthesis of the highly functionalized benzofuran core 15 from the β-keto ester in
HEPATITIS C INHIBITORS AND USES THEREOF
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, (2012/07/13)
This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
