Carbonic acid (1R,2R)-2-azido-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-phenyl)-ethyl ester phenyl ester

Base Information

Chemical Name:Carbonic acid (1R,2R)-2-azido-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-phenyl)-ethyl ester phenyl ester
CAS No.:237736-23-1
Molecular Formula:C₃₃H₃₅N₃O₅Si
Molecular Weight:581.744
Hs Code.:

Synonyms:Carbonic acid (1R,2R)-2-azido-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-phenyl)-ethyl ester phenyl ester

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Chemical Property of Carbonic acid (1R,2R)-2-azido-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-phenyl)-ethyl ester phenyl ester

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Technology Process of Carbonic acid (1R,2R)-2-azido-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-phenyl)-ethyl ester phenyl ester

There total 8 articles about Carbonic acid (1R,2R)-2-azido-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-phenyl)-ethyl ester phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1885-14-9
phenyl chloroformate

: 237736-14-0
(1R,2R)-1-Azido-3-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-phenyl)-propan-2-ol

: 237736-23-1
Carbonic acid (1R,2R)-2-azido-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-phenyl)-ethyl ester phenyl ester

Guidance literature:: With pyridine; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(99)00712-1

Reference yield:

: 237736-24-2
C₄₀H₄₀O₈Si

: 237736-23-1
Carbonic acid (1R,2R)-2-azido-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-phenyl)-ethyl ester phenyl ester

: 237736-25-3
Carbonic acid (1R,2S)-2-azido-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-phenyl)-ethyl ester phenyl ester

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; trimethylsilylazide; In acetonitrile; at -50 ℃; Yield given; Yields of byproduct given;
DOI:10.1016/S0040-4039(99)00712-1

Reference yield:

: 24393-56-4
ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate

: 237736-23-1
Carbonic acid (1R,2R)-2-azido-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-phenyl)-ethyl ester phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: AD-mix-α / 2-methyl-propan-2-ol; H2O / Ambient temperature

2: 66 percent / NaBH₄ / tetrahydrofuran / 0 °C

3: 99 percent / imidazole / dimethylformamide / 0 °C

4: pyridine / CH₂Cl₂ / 0 °C

5: TMSN₃, TMSOTf / acetonitrile; various solvent(s) / -50 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; AD-mix-α; trimethylsilyl trifluoromethanesulfonate; trimethylsilylazide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/S0040-4039(99)00712-1