2,16,17,20-tetradehydro-17-ethoxy-5-oxo-1-(p-tolylsulfonyl)aspidospermidine

Base Information

• Chemical Name: 2,16,17,20-tetradehydro-17-ethoxy-5-oxo-1-(p-tolylsulfonyl)aspidospermidine
• CAS No.: 132344-10-6
• Molecular Formula: C₂₆H₂₆N₂O₄S
• Molecular Weight: 462.569
• Mol file: 132344-10-6.mol

Synonyms:2,16,17,20-tetradehydro-17-ethoxy-5-oxo-1-(p-tolylsulfonyl)aspidospermidine

Chemical Property of 2,16,17,20-tetradehydro-17-ethoxy-5-oxo-1-(p-tolylsulfonyl)aspidospermidine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2,16,17,20-tetradehydro-17-ethoxy-5-oxo-1-(p-tolylsulfonyl)aspidospermidine

There total 2 articles about 2,16,17,20-tetradehydro-17-ethoxy-5-oxo-1-(p-tolylsulfonyl)aspidospermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

20-deethyl-2,16-didehydro-5,17-dioxo-1-(p-tolylsulfonyl)aspidospermidine (132344-08-2) + ethyl iodide (75-03-6) → (3aS,10bS,12bS)-3a,6-Diethyl-2,3,3a,12b-tetrahydro-1H,6H-6,12a-diaza-indeno[7,1-cd]fluorene-4,12-dione (132344-11-7) + 2,16,17,20-tetradehydro-17-ethoxy-5-oxo-1-(p-tolylsulfonyl)aspidospermidine (132344-10-6)

Guidance literature:

With potassium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, -25 deg C, 2) up to room temp.;

DOI:10.1021/jo00008a060

Reference yield:

20-deethyl-2,16-didehydro-5,17-dioxo-1-(p-tolylsulfonyl)aspidospermidine (132344-08-2) + ethyl iodide (75-03-6) → 2,16-didehydro-5,17-dioxo-1-(p-tolylsulfonyl)aspidospermidine (132344-09-3) + 2,16,17,20-tetradehydro-17-ethoxy-5-oxo-1-(p-tolylsulfonyl)aspidospermidine (132344-10-6)

Guidance literature:

With potassium hydride; lithium iodide; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, -25 deg C, 2) up to room temp., 5 h;

DOI:10.1021/jo00008a060

Reference yield: 89.0%

2,16,17,20-tetradehydro-17-ethoxy-5-oxo-1-(p-tolylsulfonyl)aspidospermidine (132344-10-6) → 20-deethyl-2,16-didehydro-5,17-dioxo-1-(p-tolylsulfonyl)aspidospermidine (132344-08-2)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 0.666667h; Ambient temperature;

DOI:10.1021/jo00008a060

upstream raw materials:

20-deethyl-2,16-didehydro-5,17-dioxo-1-(p-tolylsulfonyl)aspidospermidine

ethyl iodide

Downstream raw materials:

20-deethyl-2,16-didehydro-5,17-dioxo-1-(p-tolylsulfonyl)aspidospermidine