tetraethylene glycol 2-bromoacetate tosylate

Base Information

• Chemical Name: tetraethylene glycol 2-bromoacetate tosylate
• CAS No.: 313946-56-4
• Molecular Formula: C₁₇H₂₅BrO₈S
• Molecular Weight: 469.351
• Mol file: 313946-56-4.mol

Synonyms:tetraethylene glycol 2-bromoacetate tosylate

Chemical Property of tetraethylene glycol 2-bromoacetate tosylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tetraethylene glycol 2-bromoacetate tosylate

There total 3 articles about tetraethylene glycol 2-bromoacetate tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester (77544-60-6) + 2-Bromoacetyl bromide (598-21-0) → tetraethylene glycol 2-bromoacetate tosylate (313946-56-4)

Guidance literature:

With triethylamine; In dichloromethane; at -20 - 20 ℃; for 1h;

DOI:10.3390/50300620

Reference yield:

Tetraethylene glycol (112-60-7) → tetraethylene glycol 2-bromoacetate tosylate (313946-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran / 0.5 h / 0 °C

1.2: 5 h / 0 °C

2.1: triethylamine / dichloromethane / 6.08 h / 0 - 20 °C

With triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c3cc45961f

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → tetraethylene glycol 2-bromoacetate tosylate (313946-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran / 0.5 h / 0 °C

1.2: 5 h / 0 °C

2.1: triethylamine / dichloromethane / 6.08 h / 0 - 20 °C

With triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c3cc45961f

upstream raw materials:

p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester

2-Bromoacetyl bromide

Tetraethylene glycol

p-toluenesulfonyl chloride

Downstream raw materials:

{5-[2-(2-{2-[2-(toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxycarbonylmethoxy]-rubicen-12-yloxy}-acetic acid 2-(2-{2-[2-(toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-ethyl ester

Refernces

• 1、 Smet, Mario,Dehaen, Wim. "Synthesis of crown ethers containing a rubicene moiety". . p. 620 - 628. Retrieved 2007/10/03.