Technology Process of 4,5-bis(trifluoromethyl)-3-fluoro-phthalic acid
There total 5 articles about 4,5-bis(trifluoromethyl)-3-fluoro-phthalic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
chromium(VI) oxide; sulfuric acid;
In
acetic acid;
at 15 - 35 ℃;
for 20.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: iodine; sulfuric acid; periodic acid / water; acetic acid / 18 h / 70 °C
2: copper(l) iodide / 1-methyl-pyrrolidin-2-one / 22 h / 20 - 165 °C / Inert atmosphere
3: nitric acid; sulfuric acid / 3 h / 60 °C
4: cesium fluoride / N,N-dimethyl-formamide / 70 h / 20 - 120 °C / Inert atmosphere
5: chromium(VI) oxide; sulfuric acid / acetic acid / 20.5 h / 15 - 35 °C
With
chromium(VI) oxide; copper(l) iodide; sulfuric acid; iodine; nitric acid; periodic acid; cesium fluoride;
In
1-methyl-pyrrolidin-2-one; water; acetic acid; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: copper(l) iodide / 1-methyl-pyrrolidin-2-one / 22 h / 20 - 165 °C / Inert atmosphere
2: nitric acid; sulfuric acid / 3 h / 60 °C
3: cesium fluoride / N,N-dimethyl-formamide / 70 h / 20 - 120 °C / Inert atmosphere
4: chromium(VI) oxide; sulfuric acid / acetic acid / 20.5 h / 15 - 35 °C
With
chromium(VI) oxide; copper(l) iodide; sulfuric acid; nitric acid; cesium fluoride;
In
1-methyl-pyrrolidin-2-one; acetic acid; N,N-dimethyl-formamide;
