N-(5-chloropyridine-2-yl)-2-{[4-trifluoroacetyl(methyl)amino]-2-[3-(trifluoroacetylamino)propoxy]phenyl-carbonylamino}benzamide

Base Information

Chemical Name:N-(5-chloropyridine-2-yl)-2-{[4-trifluoroacetyl(methyl)amino]-2-[3-(trifluoroacetylamino)propoxy]phenyl-carbonylamino}benzamide
CAS No.:1333127-12-0
Molecular Formula:C₂₇H₂₂ClF₆N₅O₅
Molecular Weight:645.946
Hs Code.:

Synonyms:N-(5-chloropyridine-2-yl)-2-{[4-trifluoroacetyl(methyl)amino]-2-[3-(trifluoroacetylamino)propoxy]phenyl-carbonylamino}benzamide

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Chemical Property of N-(5-chloropyridine-2-yl)-2-{[4-trifluoroacetyl(methyl)amino]-2-[3-(trifluoroacetylamino)propoxy]phenyl-carbonylamino}benzamide

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Technology Process of N-(5-chloropyridine-2-yl)-2-{[4-trifluoroacetyl(methyl)amino]-2-[3-(trifluoroacetylamino)propoxy]phenyl-carbonylamino}benzamide

There total 10 articles about N-(5-chloropyridine-2-yl)-2-{[4-trifluoroacetyl(methyl)amino]-2-[3-(trifluoroacetylamino)propoxy]phenyl-carbonylamino}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 280771-61-1
N-(5-chloro-2-pyridinyl)(2-amino)phenylcarboxamide

: 1333127-11-9
2-[3-(trifluoroacetylamino)propoxy]-4-[trifluoroacetyl-(methyl)amino]benzoic acid

: 1333127-12-0
N-(5-chloropyridine-2-yl)-2-{[4-trifluoroacetyl(methyl)amino]-2-[3-(trifluoroacetylamino)propoxy]phenyl-carbonylamino}benzamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; for 48h;

Reference yield:

: 65-49-6
4-Aminosalicylic acid

: 1333127-12-0
N-(5-chloropyridine-2-yl)-2-{[4-trifluoroacetyl(methyl)amino]-2-[3-(trifluoroacetylamino)propoxy]phenyl-carbonylamino}benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 24 h

2.1: potassium carbonate / 1 h / 110 °C

3.1: hydrogenchloride / ethanol; water / 2 h

4.1: zinc; sodium hydroxide / water / 4 h / 60 °C

4.2: pH 4 - 5

5.1: sodium hydroxide; water / ethanol / 10 h / 100 °C / Sealed ampoule

5.2: pH 8 - 9

6.1: 1 h

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

With hydrogenchloride; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield:

: 552-16-9,104810-18-6
ortho-nitrobenzoic acid

: 1333127-12-0
N-(5-chloropyridine-2-yl)-2-{[4-trifluoroacetyl(methyl)amino]-2-[3-(trifluoroacetylamino)propoxy]phenyl-carbonylamino}benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 4 h

1.2: 15 h

2.1: hydrogenchloride; tin(ll) chloride / ethyl acetate; water / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

With hydrogenchloride; thionyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tin(ll) chloride; In tetrahydrofuran; water; ethyl acetate;