N-(5-chloro-2-methoxyphenyl)-2-((dimethylamino)methylene)-3-oxobutanamide

Base Information

• Chemical Name: N-(5-chloro-2-methoxyphenyl)-2-((dimethylamino)methylene)-3-oxobutanamide
• CAS No.: 1088988-35-5
• Molecular Formula: C₁₄H₁₇ClN₂O₃
• Molecular Weight: 296.754

Synonyms:N-(5-chloro-2-methoxyphenyl)-2-((dimethylamino)methylene)-3-oxobutanamide

Chemical Property of N-(5-chloro-2-methoxyphenyl)-2-((dimethylamino)methylene)-3-oxobutanamide

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Technology Process of N-(5-chloro-2-methoxyphenyl)-2-((dimethylamino)methylene)-3-oxobutanamide

There total 1 articles about N-(5-chloro-2-methoxyphenyl)-2-((dimethylamino)methylene)-3-oxobutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

acetoacetic acid-(5-chloro-2-methoxy-anilide) (52793-11-0) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → N-(5-chloro-2-methoxyphenyl)-2-((dimethylamino)methylene)-3-oxobutanamide (1088988-35-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jo801959j

Reference yield: 96.0%

2-Amino-4-methylpyridine (695-34-1) + N-(5-chloro-2-methoxyphenyl)-2-((dimethylamino)methylene)-3-oxobutanamide (1088988-35-5) → N-(5-chloro-2-methoxyphenyl)-2-(((4-methylpyridin-2-yl)-amino)methylene)-3-oxobutanamide

Guidance literature:

In ethanol; for 6h; Reflux;

DOI:10.1021/acs.joc.9b03495

Reference yield: 93.0%

N-(5-chloro-2-methoxyphenyl)-2-((dimethylamino)methylene)-3-oxobutanamide (1088988-35-5) + methylamine (74-89-5) → N-(5-chloro-2-methoxyphenyl)-2-[(methylamino)methylene]-3-oxobutanamide

Guidance literature:

In ethanol; water; at 20 ℃;

DOI:10.1055/s-0037-1609318

upstream raw materials:

acetoacetic acid-(5-chloro-2-methoxy-anilide)

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

4-bromo-1-(5-chloro-2-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbaldehyde

4-chloro-1-(5-chloro-2-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbaldehyde

2-(aminomethylene)-N-(5-chloro-2-methoxyphenyl)-3-oxobutanamide

3-(5-chloro-2-methoxyphenyl)-5-(1-chlorovinyl)pyrimidin-4(3H)-one

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