(2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-ol

Base Information

• Chemical Name: (2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-ol
• CAS No.: 63122-28-1
• Molecular Formula: C₉H₁₈O₅
• Molecular Weight: 206.239
• Mol file: 63122-28-1.mol

Synonyms:(2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-ol

Chemical Property of (2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-ol

There total 6 articles about (2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

permethylate of taccaoside (75050-63-4) → O4,O6-dimethyl-α-D-glucopyranose (24462-98-4) + 2,3,4-tri-O-methyl-L-rhamnose (4348-77-0,14187-51-0,63122-28-1,71049-57-5,71049-59-7,139628-30-1) + diosgenin (512-04-9)

Guidance literature:

With sulfuric acid; In methanol; water; at 100 ℃; for 10h;

DOI:10.1007/BF00567287

Reference yield:

2,3,8-Trimethoxy-7-[(3S,4R,5S,6S)-3,4,5-trimethoxy-6-((2S,3S,4S,5R,6R)-3,4,5-trimethoxy-6-methyl-tetrahydro-pyran-2-yloxymethyl)-tetrahydro-pyran-2-yloxy]-chromeno[5,4,3-cde]chromene-5,10-dione → 2,3,4-tri-O-methyl-D-glucopyranose (1136-20-5,1136-21-6,4239-62-7,13704-10-4,27539-49-7,32568-58-4,35775-21-4,35775-22-5,84413-48-9) + 2,3,4-tri-O-methyl-L-rhamnose (4348-77-0,14187-51-0,63122-28-1,71049-57-5,71049-59-7,139628-30-1) + 3,3',4-tri-O-methylellagic acid (1617-49-8)

Guidance literature:

With sulfuric acid; In methanol; for 6h; Heating;

DOI:10.1016/0031-9422(88)80150-X

Reference yield:

kaempferol-3-O-(6''-O-α-L-rhamnopyranosyl)-β-D-glucoside → 2,3,4-tri-O-methyl-D-glucopyranose (1136-20-5,1136-21-6,4239-62-7,13704-10-4,27539-49-7,32568-58-4,35775-21-4,35775-22-5,84413-48-9) + 2,3,4-tri-O-methyl-L-rhamnose (4348-77-0,14187-51-0,63122-28-1,71049-57-5,71049-59-7,139628-30-1) + kaempferol 5,7,4'-trimethyl ether (1098-92-6)

Guidance literature:

With hydrogenchloride; water; acetic acid; Multistep reaction;

upstream raw materials:

permethylate of taccaoside

methyl iodide

Downstream raw materials:

(S)-1-benzyl 5-((2S,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-yl) 3-methylpentanedioate