4',5,7-Trimethoxyflavonol

Base Information

• Chemical Name: 4',5,7-Trimethoxyflavonol
• CAS No.: 1098-92-6
• Molecular Formula: C18H16O6
• Molecular Weight: 328.321
• Hs Code.: 2914509090
• Mol file: 1098-92-6.mol

Synonyms:

Chemical Property of 4',5,7-Trimethoxyflavonol

Chemical Property:

• Melting Point: 150-153℃
• PSA: 78.13000
• LogP: 3.19140

Purity/Quality:

98%,99%, ^*data from raw suppliers

Kaempferol5,7,4'-trimethylether 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4',5,7-Trimethoxyflavonol

There total 38 articles about 4',5,7-Trimethoxyflavonol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4',5,7-trimethoxyflavone (5631-70-9) → kaempferol 5,7,4'-trimethyl ether (1098-92-6)

Guidance literature:

With 3,3-dimethyldioxirane; In dichloromethane; acetone; for 8h;

DOI:10.1002/jccs.200100033

Reference yield: 88.0%

3,4',5,7-tetramethoxyflavone (16692-52-7) → kaempferol 5,7,4'-trimethyl ether (1098-92-6)

Guidance literature:

3,4',5,7-tetramethoxyflavone; With aluminum tri-bromide; In acetonitrile; at 20 ℃; for 2h; Cooling with ice;

With hydrogenchloride; In acetonitrile; at 75 ℃; for 0.416667h;

Reference yield: 85.0%

C9H10O5 + 4-methoxy-benzaldehyde (123-11-5) → kaempferol 5,7,4'-trimethyl ether (1098-92-6)

Guidance literature:

With pyrrolidine; oxygen; In water; at 50 ℃; under 760.051 Torr;

DOI:10.1021/acs.joc.0c01869

upstream raw materials:

ω-benzoyloxy-4,6-dimethoxy-2-hydroxyacetophenone

p-Methoxybenzoic anhydride

(+/-)-3-hydroxy-4',5,7-trimethoxy-2,3-trans-flavanone

3,4',5,7-tetramethoxyflavone

Downstream raw materials:

3,4',5,7-tetramethoxyflavone

kaempferol

trimethoxy cyclopenta[bc]benzopyran

3,5-dimethoxyphenol

Refernces

• 1、 Alaniya et al.. "-". . . Retrieved 1975.
• 2、 Attaribo, Thomas,Gui, Zhongzheng,Huang, Gaiqun,Jin, Byung Rae,Lee, Kwang Sik,Tang, Liumei,Xin, Xiangdong,Zeng, Qinglei,Zhang, Ning,Zhang, Ran,Zhang, Yueyue. "Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway". . p. 1534 - 1543. Retrieved 2021.
• 3、 Nawwar,El Sherbeiny,El Ansari. "Plant constituents of Tamarix aphylla flowers (Tamaricaceae)". . p. 1118 - 1118. Retrieved 1975.
• 4、 -. "1-deoxynojirimycin-kaempferol compound, intermediate, preparation method and application". . . Retrieved 2020/12/31.
• 5、 Zhang, Wenhan,Liu, Shufeng,Maiga, Rayelle I.,Pelletier, Jerry,Brown, Lauren E.,Wang, Tony T.,Porco, John A.. "Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for Hepatitis C Viral Infection". . p. 1312 - 1323. Retrieved 2019/01/21.