(6S,7S,8S)-7-(4-bromophenyl)-4-((2-nitrophenyl)sulfonyl)-8-((trityloxy)methyl)-1,4-diazabicyclo[4.2.0]octan-2-one

Base Information

Chemical Name:(6S,7S,8S)-7-(4-bromophenyl)-4-((2-nitrophenyl)sulfonyl)-8-((trityloxy)methyl)-1,4-diazabicyclo[4.2.0]octan-2-one
CAS No.:1393810-09-7
Molecular Formula:C₃₈H₃₂BrN₃O₆S
Molecular Weight:738.659
Hs Code.:

Synonyms:(6S,7S,8S)-7-(4-bromophenyl)-4-((2-nitrophenyl)sulfonyl)-8-((trityloxy)methyl)-1,4-diazabicyclo[4.2.0]octan-2-one

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Chemical Property of (6S,7S,8S)-7-(4-bromophenyl)-4-((2-nitrophenyl)sulfonyl)-8-((trityloxy)methyl)-1,4-diazabicyclo[4.2.0]octan-2-one

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Technology Process of (6S,7S,8S)-7-(4-bromophenyl)-4-((2-nitrophenyl)sulfonyl)-8-((trityloxy)methyl)-1,4-diazabicyclo[4.2.0]octan-2-one

There total 9 articles about (6S,7S,8S)-7-(4-bromophenyl)-4-((2-nitrophenyl)sulfonyl)-8-((trityloxy)methyl)-1,4-diazabicyclo[4.2.0]octan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22118-09-8
2-bromoacetyl chloride

: C₃₆H₃₂BrN₃O₅S

: 1393810-09-7
(6S,7S,8S)-7-(4-bromophenyl)-4-((2-nitrophenyl)sulfonyl)-8-((trityloxy)methyl)-1,4-diazabicyclo[4.2.0]octan-2-one

Guidance literature:: C₃₆H₃₂BrN₃O₅S; With caesium carbonate; In acetonitrile; at 20 ℃; for 0.5h; Inert atmosphere;

2-bromoacetyl chloride; In acetonitrile; Inert atmosphere;
DOI:10.1021/jo300974j

Reference yield:

: 1393809-78-3
2-(allyl((1S,2R)-1-(4-bromophenyl)-1,3-dihydroxypropan-2-yl)amino)acetonitrile

: 1393810-09-7
(6S,7S,8S)-7-(4-bromophenyl)-4-((2-nitrophenyl)sulfonyl)-8-((trityloxy)methyl)-1,4-diazabicyclo[4.2.0]octan-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: pyridine; thionyl chloride / dichloromethane / 0.42 h / 0 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -50 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: 2,6-dimethylpyridine / dichloromethane / 3 h / 0 - 20 °C

6.1: 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol / 20 °C / Inert atmosphere

7.1: caesium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

7.2: Inert atmosphere

With pyridine; 2,6-dimethylpyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; 1,3-dimethylbarbituric acid; diisobutylaluminium hydride; caesium carbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jo300974j

Reference yield:

: 1393809-81-8
2-(allyl((1S,2R)-1-(4-bromophenyl)-1-hydroxy-3-(trityloxy)propan-2-yl)amino)acetonitrile

: 1393810-09-7
(6S,7S,8S)-7-(4-bromophenyl)-4-((2-nitrophenyl)sulfonyl)-8-((trityloxy)methyl)-1,4-diazabicyclo[4.2.0]octan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine; thionyl chloride / dichloromethane / 0.42 h / 0 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -50 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: 2,6-dimethylpyridine / dichloromethane / 3 h / 0 - 20 °C

5.1: 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol / 20 °C / Inert atmosphere

6.1: caesium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

6.2: Inert atmosphere

With pyridine; 2,6-dimethylpyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; 1,3-dimethylbarbituric acid; diisobutylaluminium hydride; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jo300974j