(R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate

Base Information

Chemical Name:(R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate
CAS No.:1421840-49-4
Molecular Formula:C₂₅H₂₉ClNO₄PS
Molecular Weight:506.002
Hs Code.:

Synonyms:(R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate

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Chemical Property of (R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate

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Technology Process of (R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate

There total 6 articles about (R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1421840-45-0
C₂₁H₁₉ClNO₄PS

: 594-19-4
tert.-butyl lithium

: 1421840-49-4
(R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate

Guidance literature:: C₂₁H₁₉ClNO₄PS; tert.-butyl lithium; In tetrahydrofuran; pentane; at -70 ℃; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; pentane; Inert atmosphere;
DOI:10.1021/ja312352p

Reference yield:

: 1421840-58-5
(R)-6-chloro-4-methyl-3,4-dihydro-2H-benzo[e][1,3]oxazin-2-one

: 1421840-49-4
(R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: lithium hydroxide / 60 °C / Inert atmosphere

2.2: 20 °C / pH 4 / Inert atmosphere

3.1: 1-methyl-1H-imidazole / dichloromethane / -10 - -5 °C / Inert atmosphere

4.1: tetrahydrofuran; pentane / -70 °C / Inert atmosphere

4.2: Inert atmosphere

With 1-methyl-1H-imidazole; sodium hydride; lithium hydroxide; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1021/ja312352p

Reference yield:

: 1421840-44-9
(R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide

: 1421840-49-4
(R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3,5-Lutidine / dichloromethane / -10 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran; pentane / -70 °C / Inert atmosphere

2.2: Inert atmosphere

With 3,5-Lutidine; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1021/ja312352p