(R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: (R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide
• CAS No.: 1421840-44-9
• Molecular Formula: C₁₅H₁₆ClNO₃S
• Molecular Weight: 325.816
• Mol file: 1421840-44-9.mol

Synonyms:(R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide

Chemical Property of (R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(R)-N-(1-(5-Chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide

There total 14 articles about (R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C16H14ClNO4S → (R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide (1421840-44-9)

Guidance literature:

C₁₆H₁₄ClNO₄S; With lithium hydroxide; at 60 ℃; Inert atmosphere;

With hydrogenchloride; In water; at 20 ℃; pH=4; Inert atmosphere;

DOI:10.1021/ja312352p

Reference yield: 91.0%

(R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl 3-ethylpentane-3-sulfinate + tert.-butyl lithium (594-19-4) + benzonitrile (100-47-0) → (R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide (1421840-44-9) + (R)-N-(2,2-dimethyl-1-phenylpropylidene)-3-ethylpentane-3-sulfinamide

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201301676

Reference yield: 90.0%

(R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl 1-methylcyclohexane-1-sulfinate → (R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide (1421840-44-9) + (R)-1-methylcyclohexane-1-sulfinamide

Guidance literature:

(R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl 1-methylcyclohexane-1-sulfinate; With magnesium bromide diethyl etherate; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere;

With lithium hexamethyldisilazane; In tetrahydrofuran; at -40 - 0 ℃; for 5h; Inert atmosphere;

DOI:10.1002/anie.201301676

upstream raw materials:

(R)-2-(1-aminoethyl)-4-chlorophenol

(R)-6-chloro-4-methyl-3,4-dihydro-2H-benzo[e][1,3]oxazin-2-one

tert.-butyl lithium

benzonitrile

Downstream raw materials:

((S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl)-2-methoxyphenyl(phenyl)phosphinate

(S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl-2-(1,3-dioxolan-2-yl)phenyl(phenyl)phosphinate

(S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenylmesityl(phenyl)phosphinate

(R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate