Technology Process of N-(3,4-difluorophenyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-6-amine
There total 6 articles about N-(3,4-difluorophenyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-6-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
palladium diacetate; XPhos;
In
tert-butyl alcohol;
at 110 ℃;
for 3h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1,1,1,3,3,3-hexamethyl-disilazane / toluene / 1 h / 20 °C
2.1: sodium hydroxide; methanol / 20 °C
3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 - 20 °C
3.2: 3 h / 85 °C
4.1: potassium carbonate; XPhos / palladium diacetate / tert-butyl alcohol / 3 h / 110 °C / Inert atmosphere
With
methanol; sodium hydride; potassium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; XPhos;
palladium diacetate;
In
tetrahydrofuran; toluene; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 - 20 °C
1.2: 3 h / 85 °C
2.1: potassium carbonate; XPhos / palladium diacetate / tert-butyl alcohol / 3 h / 110 °C / Inert atmosphere
With
sodium hydride; potassium carbonate; XPhos;
palladium diacetate;
In
tetrahydrofuran; tert-butyl alcohol;