n-pentyl (E)-2-benzylidene-3-oxo-3-(1H-pyrrol-2-yl)propanoate

Base Information

• Chemical Name: n-pentyl (E)-2-benzylidene-3-oxo-3-(1H-pyrrol-2-yl)propanoate
• CAS No.: 1414346-84-1
• Molecular Formula: C₁₉H₂₁NO₃
• Molecular Weight: 311.381
• Mol file: 1414346-84-1.mol

Synonyms:n-pentyl (E)-2-benzylidene-3-oxo-3-(1H-pyrrol-2-yl)propanoate

Chemical Property of n-pentyl (E)-2-benzylidene-3-oxo-3-(1H-pyrrol-2-yl)propanoate

Chemical Property:

Purity/Quality:

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Technology Process of n-pentyl (E)-2-benzylidene-3-oxo-3-(1H-pyrrol-2-yl)propanoate

There total 2 articles about n-pentyl (E)-2-benzylidene-3-oxo-3-(1H-pyrrol-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

pentan-1-ol (71-41-0) + methyl 3-oxo-3-(1H-pyrrol-2-yl)-propionate (408309-51-3) + benzaldehyde (100-52-7) → n-pentyl (E)-2-benzylidene-3-oxo-3-(1H-pyrrol-2-yl)propanoate (1414346-84-1)

Guidance literature:

pentan-1-ol; methyl 3-oxo-3-(1H-pyrrol-2-yl)-propionate; In toluene; at 120 ℃; for 12h; Molecular sieve; Inert atmosphere;

benzaldehyde; With piperidine; acetic acid; at 0 - 20 ℃; for 5h;

DOI:10.1007/s11426-012-4629-3

Reference yield:

2-Acetylpyrrole (1072-83-9) → n-pentyl (E)-2-benzylidene-3-oxo-3-(1H-pyrrol-2-yl)propanoate (1414346-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydride; sodium hydride / mineral oil; tetrahydrofuran / 3.5 h / 0 - 40 °C / Inert atmosphere

2.1: toluene / 12 h / 120 °C / Molecular sieve; Inert atmosphere

2.2: 5 h / 0 - 20 °C

With potassium hydride; sodium hydride; In tetrahydrofuran; toluene; mineral oil;

DOI:10.1007/s11426-012-4629-3

Reference yield: 87.0%

n-pentyl (E)-2-benzylidene-3-oxo-3-(1H-pyrrol-2-yl)propanoate (1414346-84-1) → C19H21NO3

Guidance literature:

With alumina-supported iron(III) perchlorate; at 80 ℃; for 4h; stereoselective reaction; Ionic liquid; Green chemistry;

DOI:10.1007/s11426-012-4629-3

upstream raw materials:

pentan-1-ol

methyl 3-oxo-3-(1H-pyrrol-2-yl)-propionate

benzaldehyde

2-Acetylpyrrole