(S)-3-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-yl]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid

Base Information

Chemical Name:(S)-3-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-yl]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid
CAS No.:1182728-16-0
Molecular Formula:C₂₂H₂₂ClN₃O₇S₂
Molecular Weight:540.018
Hs Code.:

Synonyms:(S)-3-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-yl]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid

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Chemical Property of (S)-3-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-yl]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid

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Technology Process of (S)-3-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-yl]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid

There total 6 articles about (S)-3-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-yl]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1182728-14-8
(S)-3-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-yl]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid methyl ester

: 1182728-16-0
(S)-3-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-yl]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid

Guidance literature:: (S)-3-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-yl]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid methyl ester; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

With hydrogenchloride; water; In tetrahydrofuran; methanol;

Reference yield:

: 1182728-08-0
1-benzylsulfanyl-3-bromo-2-ethylbenzene

: 1182728-16-0
(S)-3-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-yl]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 20 h / 110 °C / Inert atmosphere

2: sulfuryl dichloride; water; acetic acid / dichloromethane / 1.58 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 - 40 °C

4: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

With sulfuryl dichloride; water; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; copper(l) iodide; N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 108-36-1
1,3-dibromobenzene

: 1182728-16-0
(S)-3-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-yl]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / -78 - -65 °C / Inert atmosphere

1.2: 0.33 h / Saturated solution

2.1: n-butyllithium / tetrahydrofuran; n-heptane / 0.25 h / -78 °C

2.2: 0.5 h / -78 °C / Inert atmosphere

2.3: 1.5 h / -78 °C

3.1: potassium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 20 h / 110 °C / Inert atmosphere

4.1: sulfuryl dichloride; water; acetic acid / dichloromethane / 1.58 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 - 40 °C

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

With n-butyllithium; sulfuryl dichloride; water; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; lithium diisopropyl amide; copper(l) iodide; N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; n-heptane; dichloromethane; ethylbenzene; toluene;