tert-butyl {1-[4-(5-chloro-2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]cyclobutyl}carbamate

Base Information

Chemical Name:tert-butyl {1-[4-(5-chloro-2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]cyclobutyl}carbamate
CAS No.:1416477-56-9
Molecular Formula:C₂₇H₂₇ClN₄O₂
Molecular Weight:474.99
Hs Code.:

Synonyms:tert-butyl {1-[4-(5-chloro-2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]cyclobutyl}carbamate

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Chemical Property of tert-butyl {1-[4-(5-chloro-2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]cyclobutyl}carbamate

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Technology Process of tert-butyl {1-[4-(5-chloro-2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]cyclobutyl}carbamate

There total 3 articles about tert-butyl {1-[4-(5-chloro-2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]cyclobutyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1313883-38-3
tert-butyl (1-(4-((6-chloro-3-nitropyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

: 100-52-7
benzaldehyde

: 1416477-56-9
tert-butyl {1-[4-(5-chloro-2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]cyclobutyl}carbamate

Guidance literature:: tert-butyl (1-(4-((6-chloro-3-nitropyridin-2-yl)amino)phenyl)cyclobutyl)carbamate; benzaldehyde; With sodium dithionite; In methanol; dimethyl sulfoxide; at 100 ℃; for 22h;

With sodium hydroxide; In methanol; dimethyl sulfoxide; pH=9; Cooling with ice;

With di-tert-butyl dicarbonate; In methanol; dimethyl sulfoxide; at 20 ℃; for 2h;

Reference yield:

: 16013-85-7,136901-10-5
2,6-dicholoro-3-nitropyridine

: 1416477-56-9
tert-butyl {1-[4-(5-chloro-2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]cyclobutyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 20 °C

2.1: sodium dithionite / dimethyl sulfoxide; methanol / 22 h / 100 °C

2.2: pH 9 / Cooling with ice

2.3: 2 h / 20 °C

With sodium dithionite; In tetrahydrofuran; methanol; dimethyl sulfoxide;

Reference yield:

: C₁₆H₂₃NO₂

: 1416477-56-9
tert-butyl {1-[4-(5-chloro-2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]cyclobutyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 20 °C

2.1: sodium dithionite / dimethyl sulfoxide; methanol / 22 h / 100 °C

2.2: pH 9 / Cooling with ice

2.3: 2 h / 20 °C

With sodium dithionite; In tetrahydrofuran; methanol; dimethyl sulfoxide;