N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)methanesulfonamide

Base Information

Chemical Name:N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)methanesulfonamide
CAS No.:1430723-39-9
Molecular Formula:C₂₇H₂₆F₂N₆O₂S
Molecular Weight:536.605
Hs Code.:

Synonyms:N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)methanesulfonamide

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Chemical Property of N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)methanesulfonamide

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Technology Process of N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)methanesulfonamide

There total 13 articles about N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1430727-52-8
5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-amine

: 124-63-0
methanesulfonyl chloride

: 1430723-39-9
N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)methanesulfonamide

Guidance literature:: With pyridine; In dichloromethane; for 1h;

Reference yield:

: 18242-39-2
3,5-dinitrobromobenzene

: 1430723-39-9
N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1: acetic acid; iron / acetic acid / 0.5 h / 90 °C

2: 0.5 h / 0 - 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

5: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

6: ammonium chloride; zinc / water; tetrahydrofuran / 6 h / 20 °C

7: 0.5 h / 100 °C

8: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

9: sodium hydroxide; water / ethanol / 4 h / 100 °C

10: pyridine / dichloromethane / 1 h

With pyridine; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; palladium 10% on activated carbon; water; hydrogen; iron; sodium carbonate; ammonium chloride; acetic acid; sodium hydroxide; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 99-65-0
meta-dinitrobenzene

: 1430723-39-9
N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 11 steps

1: sulfuric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 12.5 h / 0 - 20 °C

2: acetic acid; iron / acetic acid / 0.5 h / 90 °C

3: 0.5 h / 0 - 20 °C

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

6: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

7: ammonium chloride; zinc / water; tetrahydrofuran / 6 h / 20 °C

8: 0.5 h / 100 °C

9: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

10: sodium hydroxide; water / ethanol / 4 h / 100 °C

11: pyridine / dichloromethane / 1 h

With pyridine; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; iron; sodium carbonate; ammonium chloride; acetic acid; sodium hydroxide; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;