(3-OH-4-Me-2-nitrobenzoyl)-Thr-D-Thr-(OBzl)-Pro-Sar-MeVal lactone

Base Information

Chemical Name:(3-OH-4-Me-2-nitrobenzoyl)-Thr-D-Thr-(OBzl)-Pro-Sar-MeVal lactone
CAS No.:131545-62-5
Molecular Formula:C₃₀H₄₂N₆O₁₁
Molecular Weight:662.697
Hs Code.:

Synonyms:(3-OH-4-Me-2-nitrobenzoyl)-Thr-D-Thr-(OBzl)-Pro-Sar-MeVal lactone

Suppliers and Price of (3-OH-4-Me-2-nitrobenzoyl)-Thr-D-Thr-(OBzl)-Pro-Sar-MeVal lactone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3-OH-4-Me-2-nitrobenzoyl)-Thr-D-Thr-(OBzl)-Pro-Sar-MeVal lactone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3-OH-4-Me-2-nitrobenzoyl)-Thr-D-Thr-(OBzl)-Pro-Sar-MeVal lactone

There total 10 articles about (3-OH-4-Me-2-nitrobenzoyl)-Thr-D-Thr-(OBzl)-Pro-Sar-MeVal lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 131545-61-4
(3-BzlO-4-Me-2-nitrobenzoyl)-Thr-D-Thr-(OBzl)-Pro-Sar-MeVal lactone

: 131545-62-5
(3-OH-4-Me-2-nitrobenzoyl)-Thr-D-Thr-(OBzl)-Pro-Sar-MeVal lactone

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; for 0.333333h;
DOI:10.1021/jm00108a009

Reference yield:

: 5616-82-0
N-(benzyloxycarbonyl)prolylsarcosine tert-butyl ester

: 131545-62-5
(3-OH-4-Me-2-nitrobenzoyl)-Thr-D-Thr-(OBzl)-Pro-Sar-MeVal lactone

Guidance literature:: Multi-step reaction with 8 steps

1: H₂ / Pd/C / ethanol / 16 h

2: dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 18 h / 22 °C

3: Et₂NH / CH₂Cl₂ / 5 h

4: N-hydroxy-5-norbornene-2,3-dicarboximide (HONB), dicyclohexylcarbodiimide (DCC) / 18 h / 22 °C

5: 71 percent / 4-(dimethylamino)pyridine (DMAP), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 18 h / 22 °C

6: 4 N HCl / dioxane / 2 h

7: diisopropylethylamine (DIPEA), N,N-bis(2-oxo-3-oxazolidinyl)phosphorodiamidic chloride (BOP-Cl) / CH₂Cl₂ / 96 h

8: 80 percent / trifluoromethanesulfonic acid (TFMSA) / CH₂Cl₂ / 0.33 h

With hydrogenchloride; dmap; trifluorormethanesulfonic acid; N-hydroxy-5-norbornene-2,3-dicarboximide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/jm00108a009

Reference yield:

: 2441-62-5
<3-(benzyloxy)-4-methyl-2-nitro-benzoyl>-L-threonine

: 131545-62-5
(3-OH-4-Me-2-nitrobenzoyl)-Thr-D-Thr-(OBzl)-Pro-Sar-MeVal lactone

Guidance literature:: Multi-step reaction with 5 steps

1: N-hydroxy-5-norbornene-2,3-dicarboximide (HONB), dicyclohexylcarbodiimide (DCC) / 18 h / 22 °C

2: 71 percent / 4-(dimethylamino)pyridine (DMAP), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 18 h / 22 °C

3: 4 N HCl / dioxane / 2 h

4: diisopropylethylamine (DIPEA), N,N-bis(2-oxo-3-oxazolidinyl)phosphorodiamidic chloride (BOP-Cl) / CH₂Cl₂ / 96 h

5: 80 percent / trifluoromethanesulfonic acid (TFMSA) / CH₂Cl₂ / 0.33 h

With hydrogenchloride; dmap; trifluorormethanesulfonic acid; N-hydroxy-5-norbornene-2,3-dicarboximide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00108a009