2,2-dicyclohexyl-N-{(3aR,4R,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide

Base Information

Chemical Name:2,2-dicyclohexyl-N-{(3aR,4R,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide
CAS No.:1228025-47-5
Molecular Formula:C₂₉H₄₁F₃N₂O
Molecular Weight:490.653
Hs Code.:

Synonyms:2,2-dicyclohexyl-N-{(3aR,4R,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide

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Chemical Property of 2,2-dicyclohexyl-N-{(3aR,4R,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide

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Technology Process of 2,2-dicyclohexyl-N-{(3aR,4R,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide

There total 6 articles about 2,2-dicyclohexyl-N-{(3aR,4R,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1228029-92-2
(3aR,4R,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-amine

: 52034-92-1
dicyclohexylacetic acid

: 1228025-47-5
2,2-dicyclohexyl-N-{(3aR,4R,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.04.057

Reference yield:

: 2740-83-2
3-(TRIFLUOROMETHYL)BENZYLAMINE

: 1228025-47-5
2,2-dicyclohexyl-N-{(3aR,4R,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / 16 h / 90 °C / Inert atmosphere; Neat (no solvent)

2.1: potassium carbonate / 2.5 h / 0 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

4.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 60 °C / Inert atmosphere

5.1: sodium tetrahydroborate / methanol / 16 h / -78 - 20 °C / Inert atmosphere

5.2: Inert atmosphere

6.1: hydrogenchloride; water / methanol / 0.5 h / 20 °C / Inert atmosphere

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 h / 20 °C / Inert atmosphere

With hydrogenchloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmc.2012.04.057

Reference yield:

: 1228029-88-6
(S,E)-2-methyl-N-((3aR,6aS)-2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)propane-2-sulfinamide

: 1228025-47-5
2,2-dicyclohexyl-N-{(3aR,4R,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / methanol / 16 h / -78 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: hydrogenchloride; water / methanol / 0.5 h / 20 °C / Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2012.04.057