(3aR,4R,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-amine

Base Information

Chemical Name:(3aR,4R,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-amine
CAS No.:1228029-92-2
Molecular Formula:C₁₅H₁₉F₃N₂
Molecular Weight:284.324
Hs Code.:

Synonyms:(3aR,4R,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aR,4R,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-amine

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Technology Process of (3aR,4R,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-amine

There total 7 articles about (3aR,4R,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1384106-81-3
(S)-2-methyl-N-((3aR,4R,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-yl)propane-2-sulfinamide

: 1228029-92-2
(3aR,4R,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-amine

Guidance literature:: (S)-2-methyl-N-((3aR,4R,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-yl)propane-2-sulfinamide; With hydrogenchloride; water; In methanol; at 20 ℃; for 0.5h; Inert atmosphere;

With ammonia; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2012.04.057

Reference yield:

: 2740-83-2
3-(TRIFLUOROMETHYL)BENZYLAMINE

: 1228029-92-2
(3aR,4R,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / 16 h / 90 °C / Inert atmosphere; Neat (no solvent)

2.1: potassium carbonate / 2.5 h / 0 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

4.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 60 °C / Inert atmosphere

5.1: sodium tetrahydroborate / methanol / 16 h / -78 - 20 °C / Inert atmosphere

5.2: Inert atmosphere

6.1: hydrogenchloride; water / methanol / 0.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; water; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmc.2012.04.057

Reference yield:

: 1228029-88-6
(S,E)-2-methyl-N-((3aR,6aS)-2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)propane-2-sulfinamide

: 1228029-92-2
(3aR,4R,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol / 16 h / -78 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: hydrogenchloride; water / methanol / 0.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; water; In methanol;
DOI:10.1016/j.bmc.2012.04.057