(S,E)-2-methyl-N-((3aR,6aS)-2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)propane-2-sulfinamide

Base Information

Chemical Name:(S,E)-2-methyl-N-((3aR,6aS)-2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)propane-2-sulfinamide
CAS No.:1228029-88-6
Molecular Formula:C₁₉H₂₅F₃N₂OS
Molecular Weight:386.482
Hs Code.:

Synonyms:(S,E)-2-methyl-N-((3aR,6aS)-2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)propane-2-sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,E)-2-methyl-N-((3aR,6aS)-2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)propane-2-sulfinamide

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Technology Process of (S,E)-2-methyl-N-((3aR,6aS)-2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)propane-2-sulfinamide

There total 5 articles about (S,E)-2-methyl-N-((3aR,6aS)-2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)propane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-one

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 1228029-88-6
(S,E)-2-methyl-N-((3aR,6aS)-2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)propane-2-sulfinamide

: 1228029-89-7
(S,E)-2-methyl-N-((3aS,6aR)-2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)propane-2-sulfinamide

Guidance literature:: With titanium(IV) tetraethanolate; In tetrahydrofuran; at 60 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.04.057

Reference yield:

: 1219624-35-7
1-methoxy-N-(3-(trifluoromethyl)benzyl)-N-((trimethylsilyl)methyl)methanamine

: 1228029-88-6
(S,E)-2-methyl-N-((3aR,6aS)-2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)propane-2-sulfinamide

: 1228029-89-7
(S,E)-2-methyl-N-((3aS,6aR)-2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)propane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

2: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 60 °C / Inert atmosphere

With titanium(IV) tetraethanolate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2012.04.057

Reference yield:

: 2740-83-2
3-(TRIFLUOROMETHYL)BENZYLAMINE

: 1228029-88-6
(S,E)-2-methyl-N-((3aR,6aS)-2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)propane-2-sulfinamide

: 1228029-89-7
(S,E)-2-methyl-N-((3aS,6aR)-2-(3-(trifluoromethyl)benzyl)hexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)propane-2-sulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / 16 h / 90 °C / Inert atmosphere; Neat (no solvent)

2: potassium carbonate / 2.5 h / 0 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

4: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 60 °C / Inert atmosphere

With titanium(IV) tetraethanolate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2012.04.057