7-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]quinoline

Base Information

Chemical Name:7-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]quinoline
CAS No.:1342253-50-2
Molecular Formula:C₂₂H₂₀F₃N₃O₃S
Molecular Weight:463.48
Hs Code.:

Synonyms:7-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]quinoline

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Chemical Property of 7-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]quinoline

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Technology Process of 7-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]quinoline

There total 3 articles about 7-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1078-30-4
quinoline-7-carboxylic acid

: 1204535-11-4
(3S)-3-methyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine

: 1342253-50-2
7-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]quinoline

Guidance literature:: quinoline-7-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

(3S)-3-methyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine; In N,N-dimethyl-formamide;

Reference yield:

: 74879-18-8
(S)-2-methylpiperazine

: 1342253-50-2
7-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran / 1.17 h / 0 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 2991-42-6
4-trifluorophenylsulfonyl chloride

: 1342253-50-2
7-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran / 1.17 h / 0 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;