1078-30-4

Basic information

• Product Name: 7-Quinolinecarboxylic acid
• Synonyms: QUINOLINE-7-CARBOXYLIC ACID;7-QUINOLINECARBOXYLIC ACID;AKOS BBS-00005341;7-Quinolinecarboxylic acid ,98%;7-Carboxyquinoline;quinolin-7-carboxylic acid;7-Carboxyquinoline, 7-Carboxy-1-azanaphthalene;7-Quinolinecarboxylic acid, 95+%
• CAS NO: 1078-30-4
• Molecular Formula: C₁₀H₇NO₂
• Molecular Weight: 173.17
• Product Categories: Quinoline Derivertives
• Mol File: 1078-30-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 249.5°C
• Boiling Point: 303.81°C (rough estimate)
• Flash Point: 164.7 °C
• Appearance: /
• Density: 1.2427 (rough estimate)
• Vapor Pressure: 1.85E-05mmHg at 25°C
• Refractive Index: 1.5200 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.68±0.30(Predicted)
• CAS DataBase Reference: 7-Quinolinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Quinolinecarboxylic acid(1078-30-4)
• EPA Substance Registry System: 7-Quinolinecarboxylic acid(1078-30-4)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 1078-30-4(Hazardous Substances Data)

Usage

Chemical Properties

Off-white powder

Uses

7-Quinolinecarboxylic acid is a reactant used in the chemical & genetic engineering of selective ion channel-ligand interactions.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 2721, 1946 DOI: 10.1021/ja01216a093

InChI:InChI=1/C10H7NO2/c12-10(13)8-4-3-7-2-1-5-11-9(7)6-8/h1-6H,(H,12,13)

Upstream product

• 91-22-5 quinoline 
• 612-60-2 7-methylquinoline 
• 67360-38-7 quinoline-7-carbonitrile 
• 5434-20-8 3-aminophthalic acid 
• 56-81-5 glycerol 
• 22048-88-0 1,2,3,4-tetrahydro-quinoline-7-carboxylic acid 
• 51552-68-2 quinoline-7-carboxylic acid methyl ester 
• 108-44-1 1-amino-3-methylbenzene 
• 98-16-8 3-trifluoromethylaniline 
• 99-05-8 meta-aminobenzoic acid 
• 325-14-4 7‐(trifluoromethyl)quinoline 
• 7661-47-4 7-ethylquinoline 

Downstream Products

• 928772-09-2 2-chloro-4-[(quinoline-7-carbonyl)-amino]-benzoic acid methyl ester 
• 104294-00-0 quinoline-7-carboxylic acid ethyl ester 
• 7661-47-4 7-ethylquinoline 
• 103854-57-5 1-(quinolin-7-yl)ethan-1-one 
• 1416795-97-5 (S)-N-((3-fluoro-4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)methyl)quinoline-7-carboxamide 
• 1416794-63-2 (S)-N-((3-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)methyl)quinoline-7-carboxamide 
• 1416794-65-4 (S)-N-((4-methoxyphenyl)(3-(trifluoromethyl)pyridin-2-yl)methyl)quinoline-7-carboxamide 
• 1416794-68-7 (S)-N-(m-tolyl(3-(trifluoromethyl)pyridin-2-yl)methyl)quinoline-7-carboxamide 
• 1416794-59-6 (S)-N-(p-tolyl(3-(trifluoromethyl)pyridin-2-yl)methyl)quinoline-7-carboxamide 
• 1416794-74-5 (S)-N-((4-fluorophenyl)(3-(trifluoromethyl)pyridin-2-yl)methyl)quinoline-7-carboxamide 
• 1416797-93-7 (S)-N-(phenyl(3-(trifluoromethyl)pyridin-2-yl)methyl)quinoline-7-carboxamide 
• 1416795-98-6 (S)-N-((4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)methyl)quinoline-7-carboxamide 

Relevant articles and documents

Metal-Free Dehydrogenation of N-Heterocycles by Ternary h-BCN Nanosheets with Visible Light

An efficient metal-free catalytic system has been developed based on hexagonal boron carbon nitride (h-BCN) nanosheets for the dehydrogenation of N-heterocycles with visible light; hydrogen gas is released in the process, and thus no proton acceptor is needed. This acceptorless dehydrogenation of hydroquinolines, hydroisoquinolines, and indolines to the corresponding aromatic N-heterocycles occurred in excellent yield under visible-light irradiation at ambient temperature. With h-BCN as the photocatalyst and water as the solvent, this environmentally benign protocol shows broad substitution tolerance and high efficiency.

Novel indolyl derivatives which are L-CPT1 inhibitors

The invention is concerned with novel heterobicyclic derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, A, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.