1078-30-4

Usage

Uses

Used in Chemical and Genetic Engineering:
7-Quinolinecarboxylic acid is used as a reactant for the chemical and genetic engineering of selective ion channel-ligand interactions. Its role in this application is to facilitate the development of new compounds or modifications to existing ones that can specifically target and interact with ion channels, which are crucial for various cellular functions and signaling pathways.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 7-Quinolinecarboxylic acid is used as a building block for the synthesis of various drugs, particularly those targeting ion channels. Its ability to interact with these channels makes it a promising candidate for the development of medications that can treat a range of conditions, from neurological disorders to cardiovascular diseases.
Used in Research and Development:
7-Quinolinecarboxylic acid is also used in research and development, where it serves as a key component in the design and synthesis of novel compounds with potential therapeutic applications. Its unique properties allow scientists to explore new avenues in drug discovery and to better understand the mechanisms of action of various ion channel modulators.
Used in Material Science:
In the field of material science, 7-Quinolinecarboxylic acid can be used to develop new materials with specific properties, such as those that can selectively interact with ion channels. This can lead to the creation of advanced materials for use in sensors, drug delivery systems, and other applications where precise control over ion channel interactions is required.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 2721, 1946 DOI: 10.1021/ja01216a093

InChI:InChI=1/C10H7NO2/c12-10(13)8-4-3-7-2-1-5-11-9(7)6-8/h1-6H,(H,12,13)

Upstream product

• 91-22-5 quinoline 
• 612-60-2 7-methylquinoline 
• 7661-47-4 7-ethylquinoline 
• 5434-20-8 3-aminophthalic acid 
• 56-81-5 glycerol 
• 108-44-1 1-amino-3-methylbenzene 
• 22048-88-0 1,2,3,4-tetrahydro-quinoline-7-carboxylic acid 
• 51552-68-2 quinoline-7-carboxylic acid methyl ester 
• 98-16-8 3-trifluoromethylaniline 
• 99-05-8 meta-aminobenzoic acid 
• 325-14-4 7‐(trifluoromethyl)quinoline 
• 67360-38-7 quinoline-7-carbonitrile 

Downstream Products

• 928772-09-2 2-chloro-4-[(quinoline-7-carbonyl)-amino]-benzoic acid methyl ester 
• 49713-58-8 4‐chloroquinoline‐7‐carboxylic acid 
• 1150618-22-6 4-hydroxyquinoline-7-carboxylic acid 
• 178984-69-5 7-Methyloxycarbonyl-4-chloroquinoline 
• 1416801-65-4 methyl 2-chloro-quinoline-7-carboxylate 
• 51552-68-2 quinoline-7-carboxylic acid methyl ester 
• 7661-47-4 7-ethylquinoline 
• 103854-57-5 1-(quinolin-7-yl)ethan-1-one 
• 1416795-97-5 (S)-N-((3-fluoro-4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)methyl)quinoline-7-carboxamide 
• 1416794-63-2 (S)-N-((3-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)methyl)quinoline-7-carboxamide 
• 1416794-65-4 (S)-N-((4-methoxyphenyl)(3-(trifluoromethyl)pyridin-2-yl)methyl)quinoline-7-carboxamide 

Relevant academic research and scientific papers

Metal-Free Dehydrogenation of N-Heterocycles by Ternary h-BCN Nanosheets with Visible Light

An efficient metal-free catalytic system has been developed based on hexagonal boron carbon nitride (h-BCN) nanosheets for the dehydrogenation of N-heterocycles with visible light; hydrogen gas is released in the process, and thus no proton acceptor is needed. This acceptorless dehydrogenation of hydroquinolines, hydroisoquinolines, and indolines to the corresponding aromatic N-heterocycles occurred in excellent yield under visible-light irradiation at ambient temperature. With h-BCN as the photocatalyst and water as the solvent, this environmentally benign protocol shows broad substitution tolerance and high efficiency.

ALKALOIDS OF Nitraria komarovii. VII. STRUCTURE AND SYNTHESIS OF KOMAROVININE

The new alkaloid komarovinine has been isolated from the total ether-extracted alkaloids of the epigeal part of Nitraria komarovii.It has also been found among the products of the dehydrogenation of nitrarine by selenium and sulfur.On the basis of the available facts, the structure of one of the isomers of 1-quinolinyl-β-carboline was proposed for komarovinine.A direct comparison with synthetic samples shows the identity of the alkaloid to 1-(quinolin-6'-yl)-β-carboline. 1-(Quinolin-7'-yl)-β-carboline, not previously described in the literature, has been characterized.

Novel indolyl derivatives which are L-CPT1 inhibitors

The invention is concerned with novel heterobicyclic derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, A, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.

Remarkable effect of nitrogen dioxide for N-hydroxyphthalimide-catalyzed aerobic oxidation of methylquinolines

Aerobic oxidation of methylquinolines was successfully achieved by the use of N-hydroxyphthalimide/Co(OAc)2/Mn(OAc)2 as catalyst in the presence of a small amount of nitrogen dioxide as an initiator.