(1R,2R,3S,5S,6S)-3-Azido-5-methoxy-6-methylamino-2-((2R,6S)-6-{[methyl-((R)-1-phenyl-ethyl)-amino]-methyl}-5,6-dihydro-2H-pyran-2-yloxy)-cyclohexanol

Base Information

Chemical Name:(1R,2R,3S,5S,6S)-3-Azido-5-methoxy-6-methylamino-2-((2R,6S)-6-{[methyl-((R)-1-phenyl-ethyl)-amino]-methyl}-5,6-dihydro-2H-pyran-2-yloxy)-cyclohexanol
CAS No.:213132-44-6
Molecular Formula:C₂₃H₃₅N₅O₄
Molecular Weight:445.562
Hs Code.:

Synonyms:(1R,2R,3S,5S,6S)-3-Azido-5-methoxy-6-methylamino-2-((2R,6S)-6-{[methyl-((R)-1-phenyl-ethyl)-amino]-methyl}-5,6-dihydro-2H-pyran-2-yloxy)-cyclohexanol

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Chemical Property of (1R,2R,3S,5S,6S)-3-Azido-5-methoxy-6-methylamino-2-((2R,6S)-6-{[methyl-((R)-1-phenyl-ethyl)-amino]-methyl}-5,6-dihydro-2H-pyran-2-yloxy)-cyclohexanol

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Technology Process of (1R,2R,3S,5S,6S)-3-Azido-5-methoxy-6-methylamino-2-((2R,6S)-6-{[methyl-((R)-1-phenyl-ethyl)-amino]-methyl}-5,6-dihydro-2H-pyran-2-yloxy)-cyclohexanol

There total 4 articles about (1R,2R,3S,5S,6S)-3-Azido-5-methoxy-6-methylamino-2-((2R,6S)-6-{[methyl-((R)-1-phenyl-ethyl)-amino]-methyl}-5,6-dihydro-2H-pyran-2-yloxy)-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 213132-43-5
(3aR,4S,6S,7R,7aR)-6-Azido-7-((2R,3S,6S)-3-iodo-6-{[methyl-((R)-1-phenyl-ethyl)-amino]-methyl}-tetrahydro-pyran-2-yloxy)-4-methoxy-3-methyl-hexahydro-benzooxazol-2-one

: 213132-44-6
(1R,2R,3S,5S,6S)-3-Azido-5-methoxy-6-methylamino-2-((2R,6S)-6-{[methyl-((R)-1-phenyl-ethyl)-amino]-methyl}-5,6-dihydro-2H-pyran-2-yloxy)-cyclohexanol

Guidance literature:: With sodium hydroxide; In methanol; water; for 2h; Heating;
DOI:10.1002/(SICI)1099-0690(199809)1998:9<1935::AID-EJOC1935>3.0.CO;2-Y

Reference yield:

: 91704-05-1
(2S)-2-[N-trifluoroacetyl-N-((R)-phenylethyl)aminomethyl]-3,4-dihydro-2H-pyran

: 213132-44-6
(1R,2R,3S,5S,6S)-3-Azido-5-methoxy-6-methylamino-2-((2R,6S)-6-{[methyl-((R)-1-phenyl-ethyl)-amino]-methyl}-5,6-dihydro-2H-pyran-2-yloxy)-cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1: 42 percent / acetonitrile

2: 87 percent / NaBH₄ / ethanol / 6 h / 20 °C

3: 72 percent / K₂CO₃ / acetonitrile / 2 h / 20 °C

4: 94 percent / NaOH / methanol; H₂O / 2 h / Heating

With sodium hydroxide; sodium tetrahydroborate; potassium carbonate; In methanol; ethanol; water; acetonitrile;
DOI:10.1002/(SICI)1099-0690(199809)1998:9<1935::AID-EJOC1935>3.0.CO;2-Y

Reference yield:

: 213132-41-3
N-[(2S,5S,6R)-6-((3aR,4S,6S,7R,7aR)-6-Azido-4-methoxy-3-methyl-2-oxo-octahydro-benzooxazol-7-yloxy)-5-iodo-tetrahydro-pyran-2-ylmethyl]-2,2,2-trifluoro-N-((R)-1-phenyl-ethyl)-acetamide

: 213132-44-6
(1R,2R,3S,5S,6S)-3-Azido-5-methoxy-6-methylamino-2-((2R,6S)-6-{[methyl-((R)-1-phenyl-ethyl)-amino]-methyl}-5,6-dihydro-2H-pyran-2-yloxy)-cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / NaBH₄ / ethanol / 6 h / 20 °C

2: 72 percent / K₂CO₃ / acetonitrile / 2 h / 20 °C

3: 94 percent / NaOH / methanol; H₂O / 2 h / Heating

With sodium hydroxide; sodium tetrahydroborate; potassium carbonate; In methanol; ethanol; water; acetonitrile;
DOI:10.1002/(SICI)1099-0690(199809)1998:9<1935::AID-EJOC1935>3.0.CO;2-Y