Benzene, 1-ethoxy-2-methoxy-4-(3-methyl-1-butenyl)-, (E)- (9CI)

Base Information

• Chemical Name: Benzene, 1-ethoxy-2-methoxy-4-(3-methyl-1-butenyl)-, (E)- (9CI)
• CAS No.: 195192-82-6
• Molecular Formula: C₁₄H₂₀O₂
• Molecular Weight: 220.312
• Mol file: 195192-82-6.mol

Synonyms:Benzene, 1-ethoxy-2-methoxy-4-(3-methyl-1-butenyl)-, (E)- (9CI)

Chemical Property of Benzene, 1-ethoxy-2-methoxy-4-(3-methyl-1-butenyl)-, (E)- (9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1-ethoxy-2-methoxy-4-(3-methyl-1-butenyl)-, (E)- (9CI)

There total 3 articles about Benzene, 1-ethoxy-2-methoxy-4-(3-methyl-1-butenyl)-, (E)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-iodo-propane (75-30-9) + (E)-1-ethoxy-2-methoxy-4-(2-nitrovinyl)benzene → (E)-1-ethoxy-2-methoxy-4-(3-methylbut-1-enyl)benzene (195192-82-6)

Guidance literature:

With triethyl borane; In tetrahydrofuran; hexane;

DOI:10.1021/jm401321v

Reference yield:

3-ethoxy-4-methoxybenzaldehyde (1131-52-8) → (E)-1-ethoxy-2-methoxy-4-(3-methylbut-1-enyl)benzene (195192-82-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate / 16 h / Reflux

2: triethyl borane / tetrahydrofuran; hexane

With triethyl borane; ammonium acetate; In tetrahydrofuran; hexane; 1: |Henry Nitro Aldol Condensation;

DOI:10.1021/jm401321v

Reference yield:

4-ethoxy-3-methoxybenzaldehyde (120-25-2) → (E)-1-ethoxy-2-methoxy-4-(3-methylbut-1-enyl)benzene (195192-82-6)

Guidance literature:

Yield given. Multistep reaction; 1) Et₂O, reflux, 30 min, 2) 170 deg C, 2 h;

DOI:10.1002/prac.199733901100

upstream raw materials:

4-ethoxy-3-methoxybenzaldehyde

2-iodo-propane

3-ethoxy-4-methoxybenzaldehyde

Refernces

• 1、 Schmidt, Arthur H.,Kircher, Gunnar,Spring, Mathias,Hendriok, Markus W.,Kuenz, Christian. "Oxocarbons and related compounds. 27. Synthesis of dihydrocyclobuta[a]naphthalene-1,2-diones and cyclobuta[a]naphthalene-1,2-diones via annulation of alkoxy-(1-alkenyl)benzenes with 3-chloro-3-cyclobutene-1,2-dione. Scope and limitations". . p. 564 - 574. Retrieved 2007/10/03.