Technology Process of methyl 2-(4-amino-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate
There total 5 articles about methyl 2-(4-amino-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 2-(4-(tert-butoxycarbonylamino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate;
With
hydrogenchloride; methanol;
at 20 ℃;
for 2h;
With
sodium hydrogencarbonate;
In
ethyl acetate;
pH=9 - 10;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetonitrile / 0.5 h
1.2: 20 °C
2.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C
3.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
5.1: hydrogenchloride; methanol / 2 h / 20 °C
5.2: pH 9 - 10
With
hydrogenchloride; methanol; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; hydrogen; sodium hydride; sodium carbonate; potassium carbonate;
10% Pt/activated carbon;
In
1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetonitrile / 0.5 h
1.2: 20 °C
2.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C
3.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
5.1: hydrogenchloride; methanol / 2 h / 20 °C
5.2: pH 9 - 10
With
hydrogenchloride; methanol; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; hydrogen; sodium hydride; sodium carbonate; potassium carbonate;
10% Pt/activated carbon;
In
1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
