Technology Process of methyl 2-(4-chlorophenyl)-2-{4-[(methylsulfonyl)amino]-1H-indazol-1-yl}butanoate
There total 6 articles about methyl 2-(4-chlorophenyl)-2-{4-[(methylsulfonyl)amino]-1H-indazol-1-yl}butanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetonitrile / 0.5 h
1.2: 20 °C
2.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C
3.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
5.1: hydrogenchloride; methanol / 2 h / 20 °C
5.2: pH 9 - 10
6.1: 4-methyl-morpholine / dichloromethane / 20 °C
With
4-methyl-morpholine; hydrogenchloride; methanol; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; hydrogen; sodium hydride; sodium carbonate; potassium carbonate;
10% Pt/activated carbon;
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetonitrile / 0.5 h
1.2: 20 °C
2.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C
3.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
5.1: hydrogenchloride; methanol / 2 h / 20 °C
5.2: pH 9 - 10
6.1: 4-methyl-morpholine / dichloromethane / 20 °C
With
4-methyl-morpholine; hydrogenchloride; methanol; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; hydrogen; sodium hydride; sodium carbonate; potassium carbonate;
10% Pt/activated carbon;
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C
2.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
4.1: hydrogenchloride; methanol / 2 h / 20 °C
4.2: pH 9 - 10
5.1: 4-methyl-morpholine / dichloromethane / 20 °C
With
4-methyl-morpholine; hydrogenchloride; methanol; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; hydrogen; sodium hydride; sodium carbonate;
10% Pt/activated carbon;
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
