3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(2-hydroxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline

Base Information

Chemical Name:3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(2-hydroxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline
CAS No.:1318918-49-8
Molecular Formula:C₂₂H₂₀ClN₃O₄S
Molecular Weight:457.938
Hs Code.:

Synonyms:3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(2-hydroxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline

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Chemical Property of 3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(2-hydroxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline

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Technology Process of 3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(2-hydroxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline

There total 2 articles about 3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(2-hydroxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride

: 41082-32-0
(E)-1-(5-Chloro-2-hydroxy-4-methyl-phenyl)-3-(2-hydroxy-phenyl)-propenone

: 1318918-49-8
3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(2-hydroxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline

Guidance literature:: In ethanol; for 24h; Reflux;
DOI:10.1016/j.bmcl.2011.05.061

Reference yield:

: 28480-70-8
5'-chloro-2'-hydroxy-4'-methyl acetophenone

: 90-02-8
salicylaldehyde

: 1318918-49-8
3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(2-hydroxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 10 °C

2: ethanol / 24 h / Reflux

With sodium hydroxide; In ethanol; 1: Claisen Schmidt condensation;
DOI:10.1016/j.bmcl.2011.05.061