2N-((N,N-dimethylamino)methylidene)-9-iodo-7N-(2-nitrophenylsulfonyl)-1N-(pivaloyloxy)methyl-9-deazaguanine

Base Information

Chemical Name:2N-((N,N-dimethylamino)methylidene)-9-iodo-7N-(2-nitrophenylsulfonyl)-1N-(pivaloyloxy)methyl-9-deazaguanine
CAS No.:1225194-14-8
Molecular Formula:C₂₁H₂₃IN₆O₇S
Molecular Weight:630.42
Hs Code.:

Synonyms:2N-((N,N-dimethylamino)methylidene)-9-iodo-7N-(2-nitrophenylsulfonyl)-1N-(pivaloyloxy)methyl-9-deazaguanine

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Chemical Property of 2N-((N,N-dimethylamino)methylidene)-9-iodo-7N-(2-nitrophenylsulfonyl)-1N-(pivaloyloxy)methyl-9-deazaguanine

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Technology Process of 2N-((N,N-dimethylamino)methylidene)-9-iodo-7N-(2-nitrophenylsulfonyl)-1N-(pivaloyloxy)methyl-9-deazaguanine

There total 1 articles about 2N-((N,N-dimethylamino)methylidene)-9-iodo-7N-(2-nitrophenylsulfonyl)-1N-(pivaloyloxy)methyl-9-deazaguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 396650-33-2
2-{[(dimethylamino)methylidene]amino}-3,5-dihydro-7-iodo-3-[(pivaloyloxy)methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one

: 1225194-14-8
2N-((N,N-dimethylamino)methylidene)-9-iodo-7N-(2-nitrophenylsulfonyl)-1N-(pivaloyloxy)methyl-9-deazaguanine

Guidance literature:: 2-{[(dimethylamino)methylidene]amino}-3,5-dihydro-7-iodo-3-[(pivaloyloxy)methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one; With sodium hydride; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

2-Nitrobenzenesulfonyl chloride; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.bmc.2010.01.062

Reference yield: 75.0%

: 1146952-46-6
diethyl 1,1-difluorohept-6-ynylphosphonate

: 1225194-14-8
2N-((N,N-dimethylamino)methylidene)-9-iodo-7N-(2-nitrophenylsulfonyl)-1N-(pivaloyloxy)methyl-9-deazaguanine

: 1225194-27-3
9-[7',7'-difluoro-7'-(diethylphosphono)hept-1'-ynyl]-2-N-(N,N-dimethylaminomethylidene)-7-N-(2-nitrophenyl)sulfonyl-1N-(pivaloyloxy)methyl-9-deazaguanine

Guidance literature:: diethyl 1,1-difluorohept-6-ynylphosphonate; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

2N-((N,N-dimethylamino)methylidene)-9-iodo-7N-(2-nitrophenylsulfonyl)-1N-(pivaloyloxy)methyl-9-deazaguanine; In acetonitrile; at 60 ℃; for 15h; Inert atmosphere;
DOI:10.1016/j.bmc.2010.01.062

Reference yield: 68.0%

: 1225194-25-1
diethyl 1,1-difluorooct-7-ynylphosphonate

: 1225194-14-8
2N-((N,N-dimethylamino)methylidene)-9-iodo-7N-(2-nitrophenylsulfonyl)-1N-(pivaloyloxy)methyl-9-deazaguanine

: 1225194-28-4
9-[8',8'-difluoro-8'-(diethylphosphono)oct-1'-ynyl]-2-N-(N,N-dimethylaminomethylidene)-7-N-(2-nitrophenyl)sulfonyl-1N-(pivaloyloxy)methyl-9-deazaguanine

Guidance literature:: diethyl 1,1-difluorooct-7-ynylphosphonate; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

2N-((N,N-dimethylamino)methylidene)-9-iodo-7N-(2-nitrophenylsulfonyl)-1N-(pivaloyloxy)methyl-9-deazaguanine; In acetonitrile; at 60 ℃; for 15h; Inert atmosphere;
DOI:10.1016/j.bmc.2010.01.062