9-[4',4'-difluoro-4'-(diethylphosphono)but-1'-ynyl]-2-N-(N,N-dimethylaminomethylidene)-7-N-(2-nitrophenyl)sulfonyl-1N-(pivaloyloxy)methyl-9-deazaguanine

Base Information

• Chemical Name: 9-[4',4'-difluoro-4'-(diethylphosphono)but-1'-ynyl]-2-N-(N,N-dimethylaminomethylidene)-7-N-(2-nitrophenyl)sulfonyl-1N-(pivaloyloxy)methyl-9-deazaguanine
• CAS No.: 1225194-29-5
• Molecular Formula: C₂₉H₃₅F₂N₆O₁₀PS
• Molecular Weight: 728.668
• Mol file: 1225194-29-5.mol

Synonyms:

Chemical Property of 9-[4',4'-difluoro-4'-(diethylphosphono)but-1'-ynyl]-2-N-(N,N-dimethylaminomethylidene)-7-N-(2-nitrophenyl)sulfonyl-1N-(pivaloyloxy)methyl-9-deazaguanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-[4',4'-difluoro-4'-(diethylphosphono)but-1'-ynyl]-2-N-(N,N-dimethylaminomethylidene)-7-N-(2-nitrophenyl)sulfonyl-1N-(pivaloyloxy)methyl-9-deazaguanine

There total 1 articles about 9-[4',4'-difluoro-4'-(diethylphosphono)but-1'-ynyl]-2-N-(N,N-dimethylaminomethylidene)-7-N-(2-nitrophenyl)sulfonyl-1N-(pivaloyloxy)methyl-9-deazaguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

2N-((N,N-dimethylamino)methylidene)-9-iodo-7N-(2-nitrophenylsulfonyl)-1N-(pivaloyloxy)methyl-9-deazaguanine (1225194-14-8) + diethyl 1,1-difluoro-3-propynephosphonate (126181-58-6) → 9-[4',4'-difluoro-4'-(diethylphosphono)but-1'-ynyl]-2-N-(N,N-dimethylaminomethylidene)-1N-(pivaloyloxy)methyl-9-deazaguanine + 9-[4',4'-difluoro-4'-(diethylphosphono)but-1'-ynyl]-2-N-(N,N-dimethylaminomethylidene)-7-N-(2-nitrophenyl)sulfonyl-1N-(pivaloyloxy)methyl-9-deazaguanine (1225194-29-5) + 2N-(N,N-dimethylaminomethylidene)-9-[(E)-4'-fluoro-4'-(diethylphosphono)but-3'-en-1'-ynyl]-1N-(pivaloyloxy)methyl-9-deazaguanine

Guidance literature:

diethyl 1,1-difluoro-3-propynephosphonate; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

2N-((N,N-dimethylamino)methylidene)-9-iodo-7N-(2-nitrophenylsulfonyl)-1N-(pivaloyloxy)methyl-9-deazaguanine; In acetonitrile; at 60 ℃; for 14h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.01.062

upstream raw materials:

2N-((N,N-dimethylamino)methylidene)-9-iodo-7N-(2-nitrophenylsulfonyl)-1N-(pivaloyloxy)methyl-9-deazaguanine

diethyl 1,1-difluoro-3-propynephosphonate