5-(3-fluoro-4-(trifluoromethyl)phenyl)-4-(hydroxymethyl)isoxazole-3-carboxylic acid

Base Information

Chemical Name:5-(3-fluoro-4-(trifluoromethyl)phenyl)-4-(hydroxymethyl)isoxazole-3-carboxylic acid
CAS No.:1237716-79-8
Molecular Formula:C₁₂H₇F₄NO₄
Molecular Weight:305.185
Hs Code.:

Synonyms:5-(3-fluoro-4-(trifluoromethyl)phenyl)-4-(hydroxymethyl)isoxazole-3-carboxylic acid

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Chemical Property of 5-(3-fluoro-4-(trifluoromethyl)phenyl)-4-(hydroxymethyl)isoxazole-3-carboxylic acid

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Technology Process of 5-(3-fluoro-4-(trifluoromethyl)phenyl)-4-(hydroxymethyl)isoxazole-3-carboxylic acid

There total 1 articles about 5-(3-fluoro-4-(trifluoromethyl)phenyl)-4-(hydroxymethyl)isoxazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1237716-77-6
ethyl 4-(bromomethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate

: 1237716-79-8
5-(3-fluoro-4-(trifluoromethyl)phenyl)-4-(hydroxymethyl)isoxazole-3-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In water; at 150 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 1237716-79-8
5-(3-fluoro-4-(trifluoromethyl)phenyl)-4-(hydroxymethyl)isoxazole-3-carboxylic acid

: 1237716-81-2
4-(chloromethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; In toluene; at 90 ℃; for 4h;

Reference yield:

: 22526-46-1
(2S)-3-methylbutan-2-amine

: 1237716-79-8
5-(3-fluoro-4-(trifluoromethyl)phenyl)-4-(hydroxymethyl)isoxazole-3-carboxylic acid

: 1237717-64-4
(S)-5-(3-fluoro-4-(trifluoromethyl)phenyl)-4-(hydroxymethyl)-N-(3-methylbutan-2-yl)isoxazole-3-carboxamide

Guidance literature:: (2S)-3-methylbutan-2-amine; 5-(3-fluoro-4-(trifluoromethyl)phenyl)-4-(hydroxymethyl)isoxazole-3-carboxylic acid; With triethylamine; In dichloromethane; for 0.0833333h;

In dichloromethane; ethyl acetate; for 1.5h;