4-(chloromethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride

Base Information

• Chemical Name: 4-(chloromethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride
• CAS No.: 1237716-81-2
• Molecular Formula: C₁₂H₅Cl₂F₄NO₂
• Molecular Weight: 342.077

Synonyms:4-(chloromethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride

Chemical Property of 4-(chloromethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride

Chemical Property:

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Technology Process of 4-(chloromethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride

There total 1 articles about 4-(chloromethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(3-fluoro-4-(trifluoromethyl)phenyl)-4-(hydroxymethyl)isoxazole-3-carboxylic acid (1237716-79-8) → 4-(chloromethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride (1237716-81-2)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In toluene; at 90 ℃; for 4h;

Reference yield:

4-(chloromethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride (1237716-81-2) + (1S,3R)-3-aminocyclohexan-1-ol (1110772-04-7) → 4-(chloromethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)-N-((1R,3S)-3-hydroxycyclohexyl)isoxazole-3-carboxamide (1237717-45-1)

Guidance literature:

With triethylamine; In dichloromethane; for 2h;

Reference yield:

(1R,3S)-3-aminocyclohexan-1-ol (1110772-22-9) + 4-(chloromethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride (1237716-81-2) → 4-(chloromethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)-N-((1S,3R)-3-hydroxycyclohexyl)isoxazole-3-carboxamide (1237716-83-4)

Guidance literature:

With triethylamine; In dichloromethane; for 2h;

upstream raw materials:

5-(3-fluoro-4-(trifluoromethyl)phenyl)-4-(hydroxymethyl)isoxazole-3-carboxylic acid

Downstream raw materials:

4-(chloromethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)-N-((1R,3S)-3-hydroxycyclohexyl)isoxazole-3-carboxamide

4-(chloromethyl)-5-(3-fluoro-4-(trifluoromethyl)phenyl)-N-((1S,3R)-3-hydroxycyclohexyl)isoxazole-3-carboxamide

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