ethyl <3-<<(benzyloxy)carbonyl>amino>-5-(3-fluorobenzyl)-2-oxo-1,2-dihydro-1-pyridyl>acetate

Base Information

Chemical Name:ethyl <3-<<(benzyloxy)carbonyl>amino>-5-(3-fluorobenzyl)-2-oxo-1,2-dihydro-1-pyridyl>acetate
CAS No.:147269-70-3
Molecular Formula:C₂₄H₂₃FN₂O₅
Molecular Weight:438.455
Hs Code.:

Synonyms:ethyl <3-<<(benzyloxy)carbonyl>amino>-5-(3-fluorobenzyl)-2-oxo-1,2-dihydro-1-pyridyl>acetate

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Chemical Property of ethyl <3-<<(benzyloxy)carbonyl>amino>-5-(3-fluorobenzyl)-2-oxo-1,2-dihydro-1-pyridyl>acetate

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Technology Process of ethyl <3-<<(benzyloxy)carbonyl>amino>-5-(3-fluorobenzyl)-2-oxo-1,2-dihydro-1-pyridyl>acetate

There total 6 articles about ethyl <3-<<(benzyloxy)carbonyl>amino>-5-(3-fluorobenzyl)-2-oxo-1,2-dihydro-1-pyridyl>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72287-26-4,95464-05-4
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride

: 456-41-7
1-(Bromomethyl)-3-fluorobenzene

: 147269-69-0
ethyl <3-<<(benzyloxy)carbonyl>amino>-5-iodo-2-oxo-1,2-dihydro-1-pyridyl>acetate

: 147269-70-3
ethyl <3-<<(benzyloxy)carbonyl>amino>-5-(3-fluorobenzyl)-2-oxo-1,2-dihydro-1-pyridyl>acetate

Guidance literature:: With zinc; In tetrahydrofuran;

Reference yield:

: 6332-56-5
3-nitropyridone

: 147269-70-3
ethyl <3-<<(benzyloxy)carbonyl>amino>-5-(3-fluorobenzyl)-2-oxo-1,2-dihydro-1-pyridyl>acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / H₂ / 10percent Pd/C / ethanol / 8 h / 760 Torr / Ambient temperature

2: 63 percent / Na₂CO₃ / tetrahydrofuran

3: 46 percent / N-iodosuccinimide / CH₂Cl₂ / 18 h

4: 1.) NaH / 1.) DMF, 15-25 deg C, 20 min, 2.) DMF, RT, 3 h

5: 1.) Zn, 2.) dichloro<1,1'-bis(diphenylphosphino)ferrocene>palladium(II) / 1.) THF, 20 deg C, 3 h, 2.) THF, a) RT, 5 h, b) 50 deg C, 4.5 h, c) RT, 18 h

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; hydrogen; sodium hydride; sodium carbonate; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00045a014

Reference yield:

: 33630-99-8
3-amino-2-pyridone

: 147269-70-3
ethyl <3-<<(benzyloxy)carbonyl>amino>-5-(3-fluorobenzyl)-2-oxo-1,2-dihydro-1-pyridyl>acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / Na₂CO₃ / tetrahydrofuran

2: 46 percent / N-iodosuccinimide / CH₂Cl₂ / 18 h

3: 1.) NaH / 1.) DMF, 15-25 deg C, 20 min, 2.) DMF, RT, 3 h

4: 1.) Zn, 2.) dichloro<1,1'-bis(diphenylphosphino)ferrocene>palladium(II) / 1.) THF, 20 deg C, 3 h, 2.) THF, a) RT, 5 h, b) 50 deg C, 4.5 h, c) RT, 18 h

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; sodium hydride; sodium carbonate; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00045a014