2,3-dihydro-5-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Base Information

• Chemical Name: 2,3-dihydro-5-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
• CAS No.: 105285-13-0
• Molecular Formula: C₁₇H₁₆O₄
• Molecular Weight: 284.312
• Mol file: 105285-13-0.mol

Synonyms:2,3-dihydro-5-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Chemical Property of 2,3-dihydro-5-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dihydro-5-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

There total 13 articles about 2,3-dihydro-5-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(E)-1-(2-hydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (105285-09-4) → 2,3-dihydro-5-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one (105285-13-0)

Guidance literature:

With oxygen; sodium carbonate; In methanol; at 20 ℃; for 3h; under 760.051 Torr;

DOI:10.1021/acs.joc.0c01869

Reference yield: 14.0%

(E)-1-(2-hydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (105285-09-4) → 2,3-dihydro-5-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one (105285-13-0) + 4-methoxy-benzaldehyde (123-11-5) + (2R*,3R*)-5,4'-dimethoxyflavanonol (101946-91-2,115524-13-5,115524-14-6)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In ethanol; at 0 ℃; for 24h;

Reference yield:

(E)-1-(2-hydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (105285-09-4) → 2-hydroxy-6-methoxybenzoic acid (3147-64-6) + 2,3-dihydro-5-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one (105285-13-0) + 3-hydroxy-5-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one (29219-06-5) + (Z)-4-methoxy-2-(4-methoxybenzylidene)benzofuran-3(2H)-one (86788-62-7) + 2,3-dihydro-3-hydroxy-5-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one + 4-methoxy-benzaldehyde (123-11-5)

Guidance literature:

(E)-1-(2-hydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one; With sodium carbonate; In methanol; water; at 25 - 28 ℃; for 0.5h;

With dihydrogen peroxide; In methanol; water; for 24h;

DOI:10.1016/j.tet.2017.06.064

upstream raw materials:

(E)-1-(2-hydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

2'-hydroxy-6'-methoxyacetophenone

4-methoxy-benzaldehyde

2,6-dihydroxylacetophenone

Downstream raw materials:

3-Brom-4',5-dimethoxyflavanon

8-bromo-5-methoxy-2-(4-methoxy-phenyl)-chroman-4-one

3-hydroxy-5-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

5,4'-Dimethoxyflavone