7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole

Base Information

Chemical Name:7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole
CAS No.:1433663-23-0
Molecular Formula:C₂₄H₂₁F₂N₃O₂
Molecular Weight:421.446
Hs Code.:

Synonyms:7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole

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Chemical Property of 7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole

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Technology Process of 7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole

There total 9 articles about 7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1433663-13-8
7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol

: 1433663-23-0
7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole

Guidance literature:: With chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 60 ℃; Inert atmosphere;
DOI:10.1021/acsmedchemlett.7b00178

Reference yield:

: 1433663-62-7
3-(4-amino-3-methoxyphenyl)-5,6-dihydrobenzo[d]isoxazol-7(4H)-one

: 1433663-23-0
7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole

Guidance literature:: Multi-step reaction with 5 steps

1: acetic anhydride / 1 h / Cooling

2: caesium carbonate; potassium iodide / N,N-dimethyl-formamide; acetone / 55 °C

3: acetic acid / 95 °C / Inert atmosphere

4: tetrahydrofuran / 5 h / 0 °C

5: chloro-trimethyl-silane; sodium iodide / acetonitrile / 60 °C

With chloro-trimethyl-silane; acetic anhydride; caesium carbonate; acetic acid; potassium iodide; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 1433663-73-0
N-(2-methoxy-4-(7-oxo-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-yl)phenyl)-N-(2-oxopropyl)formamide

: 1433663-23-0
7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 95 °C / Inert atmosphere

2: tetrahydrofuran / 5 h / 0 °C

3: chloro-trimethyl-silane; sodium iodide / acetonitrile / 60 °C

With chloro-trimethyl-silane; acetic acid; sodium iodide; In tetrahydrofuran; acetonitrile;